AKR1B15: A Drug Target and Biomarker for Estradiol Dehydrogenase Enzyme

Target Name: AKR1B15

NCBI ID: G441282

AKR1B15

AKR1B15: A Drug Target and Biomarker for Estradiol Dehydrogenase Enzyme

Estradiol, also known as 2-methoxyestradiol, is a natural compound that plays a crucial role in various physiological processes in the body. It is a key metabolite of the hormone estrogen, which is responsible for regulating various aspects of female reproductive system, bone health, and more. One of the enzymes involved in the metabolism of estrogen is the AKR1B15 enzyme, which is the focus of our discussion today.

The AKR1B15 enzyme is a key player in the 21-beta-hydroxylase (21-OH) gene family, which is responsible for the production of various metabolites, including estradiol. This enzyme is located on the X chromosome and has only one known substrate, 21-beta-hydroxylase B (21-OHB), which is a key precursor for estradiol.

TheAKR1B15 gene has been well studied, and several studies have identified various potential drug targets and biomarkers associated with this enzyme. One of the most promising targets is the AKR1B15 gene itself, which has been shown to be involved in various cellular processes, including cell signaling, DNA repair, and more.

In addition to its role in cellular signaling, AKR1B15 is also a potential biomarker for various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. The high-throughput screening (HTS) assays have identified several potential biomarkers for various diseases associated with the AKR1B15 enzyme, including cancer, cardiovascular disease, and neurodegenerative disorders.

The AKR1B15 gene has also been shown to be involved in various hormonal processes that are important for reproductive system development and function. The enzyme is involved in the production of estradiol, which is a key metabolite of estrogen that plays a crucial role in the development and maintenance of female reproductive system.

In addition to its role in reproductive system development, AKR1B15 is also involved in the regulation of bone health, as it is involved in the production of bone-specific minerals. The enzyme has also been shown to be involved in the regulation of cellular processes that are important for maintaining cellular homeostasis, including the production of reactive oxygen species (ROS).

The AKR1B15 gene has also been associated with various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Studies have shown that individuals with certain genetic variations in the AKR1B15 gene are at an increased risk of developing these diseases.

In addition to its association with various diseases, the AKR1B15 gene has also been shown to be involved in various cellular processes that are important for cellular signaling and metabolism. The enzyme is involved in the production of various metabolites, including estradiol, which is a key metabolite of estrogen that plays a crucial role in the development and maintenance of female reproductive system.

The AKR1B15 gene has also been shown to be involved in the regulation of cellular processes that are important for maintaining cellular homeostasis, including the production of reactive oxygen species (ROS). ROS are highly reactive molecules that can cause damage to cellular components if they are not properly regulated. The AKR1B15 gene has been shown to be involved in the production of ROS, which can help to maintain cellular homeostasis and prevent damage to cellular components.

In conclusion, AKR1B15 is a key enzyme involved in the production of estradiol, which is a crucial metabolite of estrogen that plays a crucial role in various physiological processes in the body. The AKR1B15 gene has been well studied, and several studies have identified various potential drug targets and biomarkers associated with this enzyme. The high-throughput screening (HTS) assays have identified several potential biomarkers for various diseases associated with the AKR1B15 enzyme, including cancer, cardiovascular disease, and neurodegenerative disorders. Additionally, studies have shown that individuals with certain genetic variations in the AKR1B15 gene are at an increased risk of developing various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.

Protein Name: Aldo-keto Reductase Family 1 Member B15

Functions: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439)

The "AKR1B15 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AKR1B15 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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