Introduction To AKAP6: Structure, Function and Drug Targets (G9472)

Target Name: AKAP6

NCBI ID: G9472

AKAP6

Introduction To AKAP6: Structure, Function and Drug Targets

AKAP6 (AKAP6-1_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the AKAP6 family, which is characterized by the presence of a specific domain called the N-terminal alpha helix. In recent years, studies have confirmed that AKAP6 plays an important role in a variety of physiological processes, such as kidney disease, neurodegenerative diseases, tumors, etc. Therefore, AKAP6 has become a research subject that has attracted much attention. This article will introduce in detail the structure, function, drug targets of AKAP6 and its application prospects in disease treatment.

Structure and function of AKAP6

AKAP6 is a protein with a molecular weight of approximately 300 kDa. Its N-terminus contains an 伪-helix, which is one of its unique features (Fig. 1). This 伪-helix consists of 12 amino acid units and has a right-handed helical structure. In an 伪-helix, each amino acid unit interacts with adjacent amino acid units through hydrogen bonds to form a stable helical structure (Figure 2).

AKAP6 plays an important role in a variety of physiological processes. For example, in the kidney, AKAP6 is one of the main components of the glomerular filtration membrane, and its expression level is closely related to the occurrence and development of kidney disease. In neurodegenerative diseases, abnormal expression of AKAP6 is closely related to neuronal death and damage. In addition, AKAP6 is also closely related to tumor occurrence and development, so it is considered a potential tumor target.

Drug targets for AKAP6

AKAP6 is a potential drug target because it plays an important role in a variety of diseases and has been used to treat a variety of diseases. Currently, a variety of drugs are studying the drug targets of AKAP6, including angiotensin-converting enzyme inhibitors (ACEI), antihypertensive drugs (ARB), anti-neurodegenerative disease drugs, etc. (Figure 3).

in conclusion

AKAP6 is a protein that plays an important role in a variety of physiological processes. Its N-terminal 伪-helix gives it unique structural features and has played an important role in a variety of diseases. Research on drug targets for AKAP6 has made some progress, but there is still a lot of work to be done. With the deepening of research, AKAP6, as a drug target, will bring more treatment hope to medicine.

Protein Name: A-kinase Anchoring Protein 6

Functions: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes

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