AKAP4: A Potential Drug Target and Biomarker for Protein Kinase A-anchoring Protein 4

Target Name: AKAP4

NCBI ID: G8852

AKAP4

AKAP4: A Potential Drug Target and Biomarker for Protein Kinase A-anchoring Protein 4

Introduction

Protein kinase A-anchoring protein 4 (AKAP4) is a protein that plays a crucial role in various cellular processes, including cell signaling, intracellular transport, and protein-protein interactions. AKAP4 has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in several diseases. In this article, we will provide a comprehensive overview of AKAP4, including its structure, function, and potential as a drug target and biomarker.

Structure and Function

AKAP4 is a 21-kDa protein that belongs to the A-type protein kinase (ATP-dependent) family 4. This family is characterized by the presence of a catalytic active site, a regulatory domain, and a C-terminal hypervariable region ( HVR). The HVR is responsible for the diversity of ATP-dependent protein kinases, including AKAP4.

The N-terminus of AKAP4 contains a unique region called the N-terminal hypervariable region (HVR1), which is involved in protein-protein interactions (PPIs) and is critical for AKAP4's stability and function. The HVR1 contains a putative N-terminal anchor that is involved in protein-protein interactions, which is crucial for AKAP4's stability and functions as a scaffold in various cellular processes.

The catalytic active site of AKAP4 is located in the center of the protein and is composed of an active site and two prosthetic groups. The active site is responsible for the catalytic activity of AKAP4 and is the site of protein-protein interactions that play a crucial role in various cellular processes.

Function

AKAP4 is involved in various cellular processes, including cell signaling, intracellular transport, and protein-protein interactions. It plays a crucial role in the regulation of mitochondrial dynamics, and it is involved in the delivery of intracellular vesicles to the mitochondrial membrane.

In addition to its role in intracellular transport, AKAP4 is also involved in protein-protein interactions. It forms a protein-protein interaction network with various protein partners, including other APKs, PKAs, and transcription factors. The interactions between AKAP4 and Its protein partners play a crucial role in regulating cellular processes and are involved in various diseases, including cancer, neurodegenerative diseases, and diseases associated with protein misfolding.

Potential as a Drug Target

The potential of AKAP4 as a drug target is due to its unique structure and function. The N-terminal HVR1 is involved in protein-protein interactions and is a scaffold that can interact with various protein partners, making it an attractive target for small molecules. Additionally, the catalytic active site of AKAP4 is known to be involved in protein-protein interactions and can serve as a target for drugs that inhibit protein-protein interactions.

AKAP4 has also been shown to be involved in various diseases, including cancer, neurodegenerative diseases, and diseases associated with protein misfolding. For example, AKAP4 has been shown to be involved in the regulation of mitochondrial dynamics and has been implicated in the development and progression of various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Additionally, AKAP4 has been shown to be involved in the regulation of protein misfolding, which is a leading cause of protein-related diseases, including neurodegenerative diseases.

Biomarker Potential

The potential of AKAP4 as a biomarker for various diseases is due to its involvement in the regulation of cellular processes and its unique structure. The N-terminal HVR1 is involved in protein-protein interactions and can serve as a

Protein Name: A-kinase Anchoring Protein 4

Functions: Major structural component of sperm fibrous sheath. Plays a role in sperm motility

The "AKAP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AKAP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets