CACNG8: A voltage-dependent calcium channel subunit as a drug target and biomarker

Target Name: CACNG8

NCBI ID: G59283

CACNG8

Other Name(s): Voltage-dependent calcium channel gamma-8 subunit | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | Transmembrane AMPAR regulatory protein gamma-8 | transmembrane AMPAR regulatory protein gamma-8 | neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | calcium channel, voltage-dependent, gamma subunit 8 | Calcium voltage-gated channel auxiliary subunit gamma 8 | calcium voltage-gated channel auxiliary subunit gamma 8

CACNG8: A voltage-dependent calcium channel subunit as a drug target and biomarker

Introduction

Ca2+ is a vital signaling molecule that plays a crucial role in various physiological processes, including muscle contractions, nerve impulse conduction, and cell signaling. During its signaling process, Ca2+ interacts with various proteins, including voltage-dependent calcium channels (VDCs), which are responsible for mediating the rapid changes in membrane potential upon Ca2+ entry. The CACNG8 subunit, a voltage-dependent calcium channel, has been identified as a potential drug target and biomarker for various neurological and cardiovascular diseases.

CACNG8: Structure and function

The CACNG8 subunit is a member of the voltage-dependent calcium channel (VDC) family, which includes several subunits, including the Ca2+-activated chloride channels (CACh channels), the voltage-dependent sodium channels (VDS channels), and the calcium ions Channel chaperone (Ca2+-ATP-dependent channels) channels. CACNG8 is characterized by its unique subunit structure, which consists of a catalytic 伪-helix, a 尾-sheet, and a 纬-helix.

The CACNG8 subunit functions as a voltage-dependent calcium channel, allowing it to regulate the movement of Ca2+ into the cell membrane. The channel is activated by changes in membrane potential, which can be triggered by various factors, such as changes in the levels of intracellular Ca2+ or by the application of agonists. Once the channel is activated, the Ca2+ ion can enter the cell, leading to a rapid increase in the cytosolic Ca2+ concentration, which can then trigger a variety of downstream signaling pathways.

CACNG8 as a drug target

The CACNG8 subunit has been identified as a potential drug target due to its involvement in various neurological and cardiovascular diseases. Several studies have demonstrated that alterations in the CACNG8 gene have been associated with a range of disorders, including epilepsy, parkinsonism, and cardiovascular disease. In addition, the CACNG8 subunit has been shown to play a key role in the development of certain neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

The potential therapeutic benefits of targeting CACNG8 arise from its ability to modulate the activity of Ca2+ channels, which are involved in a wide range of physiological processes, including muscle contractions, nerve impulses, and cell signaling. By selectively targeting the CACNG8 subunit, researchers can potentially reduce the effects of Ca2+ on these processes, leading to improved patient outcomes.

CACNG8 as a biomarker

In addition to its potential therapeutic benefits, the CACNG8 subunit has also been shown to be a promising biomarker for various neurological and cardiovascular diseases. The CACNG8 gene has been shown to be aberrantly expressed in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease , and Huntington's disease. Similarly, altered levels of the CACNG8 subunit have been observed in the brains of patients with these disorders.

The potential use of CACNG8 as a biomarker for diagnostic purposes is a promising development in the field of neurology. By analyzing the expression and distribution of CACNG8 in the brain, researchers may be able to identify early signs of neurodegeneration and disease, potentially allowing for the diagnosis and treatment of these conditions at an early stage.

Conclusion

In conclusion, the CACNG8 subunit is a voltage-dependent calcium channel that has been identified as a potential drug target and biomarker for various neurological and cardiovascular diseases. Its unique subunit structure and its involvement in the regulation of Ca2+ ion movement make it an attractive target for therapeutic intervention. Further research is needed to fully understand the role of CACNG8 in

Protein Name: Calcium Voltage-gated Channel Auxiliary Subunit Gamma 8

Functions: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits

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•   expression level;
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