Target Name: H2BW1
NCBI ID: G158983
Review Report on H2BW1 Target / Biomarker Content of Review Report on H2BW1 Target / Biomarker
H2BW1
Other Name(s): H2B histone family member W, testis specific | H2B histone family member W testis-specific | Histone H2B type W-T | TH2B-175 | H2B.W histone 1 | H2BFWT | histone H2B type W-T | H2BWT_HUMAN

H2BW1: A Potential Drug Target and Biomarker for Various Diseases

Histones are small, positively charged proteins that play a critical role in the regulation of gene expression and cell behavior. The H2B gene family is one of the most well-studied histone families, and member W, also known as H2BW1, has been identified as a potential drug target and biomarker for various diseases.

The H2B gene family consists of four subclasses: H2BW0, H2BW1, H2BW2, and H2BW3. H2BW1 is a 21-kDa protein that is highly conserved across species and has been shown to play a critical role in the regulation of cell growth, differentiation, and stress resistance.

H2BW1 functions as a negative regulator of the running replication complex, which is responsible for the efficient replication of DNA in eukaryotic cells. The H2BW1 protein forms a complex with the histone H3K9me3, which is the target of many drugs that are used to treat cancer, such as taxanes and vinca alkaloids. This interaction between H2BW1 and H3K9me3 makes H2BW1 a potential drug target for cancer treatment.

In addition to its role in cell growth and replication, H2BW1 has also been shown to play a role in the regulation of cell stress and stress resistance. The H2BW1 protein has been shown to interact with the transcription factor p53 and promote the expression of genes involved in stress response, such as the stress-responsive gene HSP70. This suggests that H2BW1 may play a role in the regulation of cellular stress responses and that targeting this protein may be a promising strategy for the treatment of stress-related diseases.

H2BW1 has also been shown to be involved in the regulation of cell adhesion and migration. The H2BW1 protein has been shown to interact with the adhesion molecule E-cadherin and promote the migration of cancer cells. This suggests that H2BW1 may play a role in the regulation of cell adhesion and migration, which could be a potential strategy for the treatment of cancer.

Furthermore, H2BW1 has also been shown to play a role in the regulation of cell survival and apoptosis. The H2BW1 protein has been shown to interact with the B-cell kinase tyrosine kinase and promote the expression of genes involved in cell survival and apoptosis, such as the tumor suppressor gene p53. This suggests that H2BW1 may play a role in the regulation of cell survival and apoptosis, which could be a potential strategy for the treatment of diseases associated with these processes, such as cancer.

In conclusion, H2BW1 is a well-studied protein that has been shown to play a critical role in the regulation of cell growth, differentiation, stress resistance, and cell adhesion and migration. The H2BW1 protein is highly conserved across species and has been shown to interact with a variety of transcription factors and proteins involved in cellular processes. This suggests that targeting this protein may be a promising strategy for the treatment of various diseases. Further research is needed to fully understand the mechanisms of H2BW1 and its potential as a drug target and biomarker.

Protein Name: H2B.W Histone 1

Functions: Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function

The "H2BW1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H2BW1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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