Unlocking The Potential of Histone H4 (G8359)

Target Name: H4C1

NCBI ID: G8359

H4C1

Other Name(s): Histone H4 | histone cluster 1 H4 family member a | H4C14 | histone 1, H4a | translation initiation factor IF-2-like | H4FA | H4C8 | HIST1H4A | H4_HUMAN | H4C12 | H4C11 | H4C9 | H4/a | H4C5 | H4 clustered histone 1 | H4C6 | H4C16 | H4C15 | H4C3 | H4 histone family, member A | histone cluster 1, H4a | H4C4 | H4C13 | H4C2 | H4-16

Unlocking The Potential of Histone H4

Histone H4 (H4) is a protein that plays a critical role in the structure and function of chromatin. It is one of the four histone proteins that make up the nucleosome, which is the basic unit of chromatin. Histone H4 is composed of two subunits, H4伪 and H4尾, and is held together by a disulfide bond.

H4 is a small protein that contains only 110 amino acid residues. It is characterized by a number of unique features, including a single transmembrane domain, a highly conserved N-terminal region, and a unique C-terminal region that contains a farnesylated cysteine residue.

One of the unique functions of H4 is its ability to interact with other proteins. H4 has been shown to interact with a wide range of proteins, including transcription factors, DNA-binding proteins, and proteins involved in cell signaling. This interaction with other proteins makes H4 an attractive target for drug development.

In addition to its potential as a drug target, H4 is also a potential biomarker. The levels of H4 have been shown to be altered in a variety of diseases, including cancer, neurodegenerative diseases, and mental disorders. This suggests that H4 may be a useful diagnostic or therapeutic target.

One way to study the interaction between H4 and other proteins is through cell-based assays. These assays involve growing cells in culture and then treating the cells with small molecules that interact with H4. The levels of H4 and the activity of the interacting proteins can then be measured, providing insight into the strength and specificity of the interaction.

Another approach to studying the interaction between H4 and other proteins is through biochemical assays. These assays involve the use of specific antibodies to detect the interaction between H4 and other proteins. The results of these assays can be used to determine the strength and specificity of the interaction.

In addition to its potential as a drug target and biomarker, H4 is also of interest to researchers because of its unique structure and function. The N-terminal region of H4 contains a farnesylated cysteine residue, which is unusual for a protein that is not involved in any cellular processes. This suggests that H4 may have unique mechanisms for interacting with other proteins and may be a useful study system for exploring the mechanisms of protein interaction.

Overall, H4 is a unique and fascinating protein that has a wide range of potential applications in research and medicine. Its ability to interact with other proteins and its unique structure and function make it an attractive target for drug development and other applications. Further research is needed to fully understand the role of H4 in cellular processes and to explore its potential as a drug and biomarker.

Protein Name: H4 Clustered Histone 1

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

The "H4C1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H4C1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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