H3C13: A Promising H2A.2-Related Compound with Potential as A Drug Target Or Biomarker
H3C13: A Promising H2A.2-Related Compound with Potential as A Drug Target Or Biomarker
Histone cluster 2 (H2A.2) is a protein that plays a critical role in cell signaling and DNA replication. Mutations in the H2A.2 gene have been linked to various diseases, including cancer. One of the most promising H2A.2-related compounds is H3C13 (histone cluster 2 H3 family member d), a potential drug target or biomarker.
H3C13 is a 21-kDa protein that belongs to the histone cluster 2 family. It is a key component of the nucleosome, which is the basic unit of chromatin. The nucleosome is composed of a protein complex called histone proteins, which include H1, H2A, H2B, H3, and H4. H3 is the largest of the histone proteins and is responsible for the overall structure of the nucleosome.
H3C13 functions as a negative regulator of the histone cycle. It interacts with the histone bundle and prevents the association of new histones with the nuclear envelope. This is important for maintaining the stability of the chromatin structure and for regulating the cell cycle.
H3C13 is also involved in the regulation of DNA replication. During DNA replication, H3C13 interacts with the enzyme responsible for copying DNA, called DNA polymerase. By interacting with DNA polymerase, H3C13 can prevent the enzyme from using an abnormally short piece of DNA as a template to synthesize a new DNA strand. This ensures that each new DNA strand that is synthesized contains the correct sequence.
H3C13 has also been shown to play a role in the regulation of cell signaling pathways. It has been shown to interact with various signaling molecules, including the oncogene transforming growth factor (TGF-2) and the tumor suppressor protein p53. This suggests that H3C13 may be a potential drug target or biomarker for diseases associated with these signaling pathways.
One of the most promising aspects of H3C13 is its potential as a drug target. H3C13 has been shown to interact with various small molecules, including inhibitors of the TGF-2 signaling pathway. This suggests that H3C13 may be a good candidate for drugs that are designed to inhibit this pathway.
In addition to its potential as a drug target, H3C13 also has the potential as a biomarker. Its involvement in the regulation of the nucleosome and DNA replication makes it an attractive candidate for diagnostic tests for various diseases. For example, H3C13 has been shown to be altered in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that H3C13 may be a useful biomarker for these diseases.
In conclusion, H3C13 is a promising protein that has the potential to be a drug target or biomarker for various diseases. Its role in the regulation of the nucleosome and DNA replication, as well as its involvement in cell signaling pathways, make it an attractive candidate for further study. Further research is needed to fully understand the biology of H3C13 and its potential as a drug or biomarker.
Protein Name: H3 Clustered Histone 13
Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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