Understanding Histone 1: A Potential Drug Target (G8363)

Target Name: H4C11

NCBI ID: G8363

H4C11

Other Name(s): histone 1, H4j | Histone H4 | HIST4H4C | H4C14 | H4 histone family, member E | HIST1H4J | translation initiation factor IF-2-like | H4/e | HIST4H4D | H4C8 | HIST4H4B | HIST4H4K | H4_HUMAN | H4C12 | TEVANED2 | H4C9 | HIST4H4I | H4F2iv | HIST4H4 | dJ160A22.2 | H4C5 | HIST2H4A | histone cluster 1, H4j | DJ160A22.2 | HIST4H4A | HIST2H4B | H4C6 | H4C16 | H4C15 | H4C3 | HIST4H4L | H4C1 | HIST4H4H | H4FE | HIST4H4F | H4C4 | H4/E | H4C13 | H4C2 | H4 clustered histone 11 | HIST4H4E | H4-16 | histone cluster 1 H4 family member j

Understanding Histone 1: A Potential Drug Target

Histone 1, also known as H4j, is a protein that is found in almost all cells of the human body. It plays a critical role in the regulation of gene expression and cell development. Despite its importance, histone 1 has remained a difficult target for drug develops due to its complex structure and the lack of small molecules that can interact with it.

The histone 1 protein is made up of four subunits that are held together by disulfide bonds. The subunits are composed of a variable region and a constant region. The variable region contains the amino acids that are responsible for the protein's unique structure and function. The constant region contains the amino acids that are held together by disulfide bonds and are responsible for maintaining the overall structure of the protein.

One of the challenges in studying histone 1 is its difficult to study. due to its complex structure and the lack of small molecules that can interact with it, researchers have had difficulty developing techniques to study it in depth. While several studies have investigated the histone 1 protein, there is still much that is not known about its functions and interactions.

Despite its challenges, histone 1 is still a promising drug target. The histone 1 protein plays a critical role in the regulation of gene expression and cell development, which makes it an attractive target for drugs that are aimed at treating diseases that are caused by the misregulation of gene expression. Additionally, the histone 1 protein is known to be involved in several cellular processes, which makes it an attractive target for drugs that are aimed at treating diseases caused by the disruption of these processes.

One of the promising compounds that have been shown to interact with histone 1 is the drug sunitinib. Sunitinib is an inhibitor of the protein tyrosine kinase, which is an enzyme that is involved in the regulation of gene expression and cell development. By inhibiting this enzyme , sunitinib has been shown to decrease the levels of histone 1 in cancer cells, which has led to the inhibition of gene expression and cell growth.

Another compound that has been shown to interact with histone 1 is the drug erbituximab. Ersentin is a monoclonal antibody that binds to specific sites on histone 1 and inhibits its function. By inhibiting the function of histone 1, erogenin has been used to treat a variety of cancers, including breast and colon cancer.

In addition, histone 1 also plays a critical role in the regulation of cell apoptosis, which is the process by which cells decide when to die. studies have shown that histone 1 is involved in the regulation of cell apoptosis, which makes it an attractive target for drugs that are aimed at treating diseases caused by the disruption of this process.

In conclusion, histone 1 is a protein that plays a critical role in the regulation of gene expression and cell development. Despite its challenges, it is still a promising drug target for the treatment of diseases caused by the misregulation of gene expression. The drug sunitinib and erxin have been shown to interact with histone 1 and have been used in the treatment of cancer. Further studies are needed to fully understand the functions and interactions of histone 1 and its potential as a drug target.

Protein Name: H4 Clustered Histone 11

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

The "H4C11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H4C11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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