Histone Modification: H2BW2 as A Cancer Drug Target (G286436)

Histone Modification: H2BW2 as A Cancer Drug Target

Histone modification is a post-translational modification that involves the addition or removal of histone modifications to the histones of the nuclear chromatin. These modifications play a crucial role in regulating gene expression, DNA replication, and chromatin stability. One of the most well-known histone modifications is H2B.W histone 2 (H2BW2), which is a type of histone modification that has been identified as a potential drug target in cancer.

H2BW2 is a histone modification that involves the addition of a second histone molecule (H2B) to a histone tertiary structure. This modification is typically performed by the enzyme histone acetyltransferase (HAT), which adds the acetyl group to the alpha-tertiary structure of the histone. H2BW2 is named after the H2B molecule, which is a key component of the histone complex.

H2BW2 has been shown to play a role in a wide range of cellular processes, including cell growth, differentiation, and response to stimuli. For example, H2BW2 has been shown to be involved in the regulation of cell cycle progression, where it helps to keep cells in the G1 phase by preventing the metaphase transition. H2BW2 has also been shown to play a role in the regulation of cell adhesion, where it helps to maintain the integrity of tight junctions between cells.

In addition to its role in cellular processes, H2BW2 has also been shown to be a potential drug target in cancer. Many studies have suggested that H2BW2 may be involved in the regulation of cancer cell growth and survival, and that targeting this modification may be a promising strategy for the development of cancer therapies. For example, studies have shown that inhibiting H2BW2 activity can lead to a reduction in cancer cell proliferation and a delay in the progression of cancer.

Furthermore, H2BW2 has also been shown to be involved in the regulation of cellular memory, where it helps to maintain the stability of chromatin domains. This is an important aspect of cellular memory, as it allows cells to store and retrieve information about their environment and to maintain the consistency of their genetic information.

In conclusion, H2BW2 is a well-known histone modification that has been shown to play a role in a wide range of cellular processes. Its potential as a drug target makes it an attractive target for the development of cancer therapies. Further research is needed to fully understand the mechanisms of H2BW2 and its role in cellular processes, as well as its potential as a drug target in cancer.

Protein Name: H2B.W Histone 2

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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More Common Targets

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