NDFIP2: A Potential Drug Target and Biomarker (G54602)

Target Name: NDFIP2

NCBI ID: G54602

NDFIP2

NDFIP2: A Potential Drug Target and Biomarker

Non-coding RNA (ncRNA) families play a crucial role in gene regulation and are involved in various cellular processes. One of the ncRNA families that has garnered significant attention in recent years is the NDFIP2 family. NDFIP2 is a non-coding RNA that has been identified as a potential drug target and biomarker. In this article, we will discuss the NDFIP2 family, its function, potential drug targets, and its potential as a biomarker.

The NDFIP2 Family

The NDFIP2 family consists of four genes: NDFIP2, NDFIP3, NDFIP4, and NDFIP5. All of these genes belong to the NDFIP2 gene family, which is located on chromosome 6p12.2. The NDFIP2 family is characterized by the presence of a unique N-terminus and a conserved C-terminus.

Function of NDFIP2

NDFIP2 is a non-coding RNA that plays a role in the regulation of gene expression. It is expressed in various tissues and cells of the body, including the brain, heart, and pancreas. NDFIP2 is involved in the regulation of gene expression by binding to specific DNA sequences and modulating the activity of transcription factors.

Potential Drug Targets

NDFIP2 has been identified as a potential drug target due to its involvement in various cellular processes. One of the potential drug targets for NDFIP2 is its role in the regulation of cellular stress responses. NDFIP2 has been shown to play a role in the regulation of stress-induced gene expression and has been shown to interact with various stress-responsive transcription factors.

Another potential drug target for NDFIP2 is its role in the regulation of cellular proliferation. NDFIP2 has been shown to play a role in the regulation of cell proliferation and has been shown to interact with various cell proliferation-related transcription factors.

Potential Biomarkers

NDFIP2 has also been identified as a potential biomarker for various diseases. For example, NDFIP2 has been shown to be downregulated in various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. This suggests that NDFIP2 may be a promising biomarker for these diseases.

Conclusion

In conclusion, the NDFIP2 family is a non-coding RNA that has the potential to be a drug target and biomarker. Its function in the regulation of gene expression and its potential as a drug target and biomarker make it an attractive target for research and development. Further studies are needed to fully understand the function of NDFIP2 and its potential as a drug and biomarker.

Protein Name: Nedd4 Family Interacting Protein 2

Functions: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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