GTF2H2D: A Potential Drug Target for Cancer and Chronic Pain (G730394)

Target Name: GTF2H2C_2

NCBI ID: G730394

GTF2H2C_2

Other Name(s): GTF2H2D | general transcription factor IIH polypeptide 2-like protein | general transcription factor IIH, polypeptide 2D | GTF2H2 family member C, copy 2, transcript variant 1 | General transcription factor IIH subunit 2-like protein (isoform 1) | T2H2L_HUMAN | GTF2H2 family member C, copy 2 | General transcription factor IIH polypeptide 2-like protein | General transcription factor IIH subunit 2-like protein

GTF2H2D: A Potential Drug Target for Cancer and Chronic Pain

GTF2H2C_2 (GTF2H2D), a protein encoded by the gene GTF2H2C_2, has been identified as a potential drug target (or biomarker) for the treatment of various diseases, including cancer. The GTF2H2D protein is a member of the GTF2H2 family, which plays a crucial role in the development and maintenance of tissues, including the nervous system and endocrine system.

The GTF2H2D protein is expressed in various tissues and cells throughout the body, including the brain, adrenal glands, liver, and muscle. It is involved in the development and maintenance of neural circuits, which are responsible for transmitting signals between different parts of the brain and ensuring proper function. The protein is also involved in the regulation of ion channels and neurotransmitter release, which are critical for the flow of electrical signals in the brain.

In addition to its role in neural circuits, GTF2H2D is also involved in the regulation of body weight and metabolism. It is expressed in the hypothalamus, which is a critical region of the brain that regulates hunger and thirst, as well as the production of hormones that control body weight and metabolism.

GTF2H2D has also been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that high levels of GTF2H2D are associated with poor prognosis in patients with pancreatic cancer, a highly aggressive form of cancer that is characterized by the formation of tumors in the pancreas, a gland located behind the stomach.

In addition to its association with cancer, GTF2H2D is also involved in the regulation of pain perception. It is expressed in the diencephalon, which is the central part of the brain that is responsible for the processing of pain signals. Research shows that GTF2H2D plays a critical role in the regulation of pain sensitivity, and may be a potential drug target for the treatment of chronic pain.

The potential drug targets for GTF2H2D are vast and varied. Some studies have suggested that GTF2H2D may be a potential drug target for the treatment of depression, anxiety, and other mood disorders. This is because GTF2H2D has been shown to play a role in the regulation of neurotransmitter release and ion channels in these conditions.

Another potential drug target for GTF2H2D is the treatment of chronic pain. As mentioned earlier, GTF2H2D is involved in the regulation of pain perception, and may be a potential drug target for the treatment of chronic pain. Studies have shown that blocking GTF2H2D with small molecules can effectively alleviate pain in animal models of chronic pain, suggesting that it may be a promising new treatment option.

In addition to its potential as a drug target, GTF2H2D is also a valuable biomarker for the diagnosis and prognosis of various diseases. For example, high levels of GTF2H2D have been shown to be associated with poor prognosis in patients with pancreatic cancer, and may be a useful biomarker for this disease. Similarly, GTF2H2D has been shown to be involved in the regulation of body weight and metabolism, and may be a useful biomarker for the diagnosis and treatment of obesity.

In conclusion, GTF2H2D is a protein that plays a critical role in the development and maintenance of tissues and cells throughout the body. Its involvement in neural circuits, body weight and metabolism, and pain perception make it a potential drug target for the treatment of various diseases, including cancer and chronic pain. Further research is needed to fully understand the role of GTF2H2D in these conditions and to develop effective treatments.

Protein Name: GTF2H2 Family Member C, Copy 2

Functions: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II

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•   expression level;
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