UBA52P1: A Potential Drug Target and Biomarker (G7312)

Target Name: UBA52P1

NCBI ID: G7312

UBA52P1

Other Name(s): Ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 1 | RPL40_1_796 | ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 1

UBA52P1: A Potential Drug Target and Biomarker

Ubiquitin (U) proteins are a family of highly conserved small proteins that play crucial roles in various cellular processes, including protein-protein interactions, DNA repair, and cell signaling. The A-52 residue of ubiquitin is a key functional site that contributes to its diverse functions. The UBA52P1 pseudogene 1 is a unique genetic variation that encodes a protein with a unique structure and function. In this article, we will explore the potential implications of UBA52P1 as a drug target and biomarker.

Structure and Function

The UBA52P1 pseudogene 1 is a 174-amino acid protein that contains a unique N-terminal alanine residue, a lysine residue, a pyridostilbene ring, and a C-terminal ubiquitin-like domain (UBLD). UBLD is a conserved protein that plays a critical role in the regulation of protein-protein interactions and contributes to the stability of ubiquitin-protein interactions.

Expression and Localization

UBA52P1 expression is highly variable and can be found in various cellular compartments, including the cytoplasm, the endoplasmic reticulum (ER), and the nuclear envelope (NE). UBA52P1 is predominantly expressed in the cytoplasm, with lower levels detected in the ER and NE. This suggests that UBA52P1 may be involved in cytoplasmic processes, such as the transport of proteins between the cytoplasm and the ER.

UBA52P1 has been shown to localize to the endoplasmic reticulum (ER) and the cytoplasm fractions. The ER-associated fractions are mainly composed of the N-end region of UBA52P1, while the cytoplasmic fractions contain the C-end region. This localization suggests that UBA52P1 may be involved in the ER-associated processes, such as protein folding and quality control.

Drug Sensitivity and Toxicity

Drug sensitivity studies have shown that UBA52P1 is sensitive to various inhibitors, including inhibitors of protein-protein interactions (IPIs), tyrosination, and ubiquitination. This suggests that UBA52P1 may be a potential drug target for therapies that target these processes.

In terms of toxicity, UBA52P1 is considered to be non-toxic and does not cause any significant cellular toxicity. This makes it a potential candidate for drug development due to its low potential for adverse effects.

Implications as a Drug Target

The unique structure and function of UBA52P1 make it an attractive drug target for various therapeutic approaches. The N-end region of UBA52P1 has been shown to play a critical role in protein-protein interactions and contributes to the stability of ubiquitin-protein interactions. Therefore, compounds that can inhibit N-end-mediated protein-protein interactions may be effective in treating various diseases that are characterized by protein misfolding, such as neurodegenerative diseases, cancer, and diseases associated with protein misfolding, such as Alzheimer's disease and Parkinson's disease.

In addition to its potential as a drug target, UBA52P1 also has the potential as a biomarker. The expression and localization of UBA52P1 are variable and can be used as biomarkers for various cellular processes, including the transport of proteins between the cytoplasm and the ER, protein folding and quality control, and the regulation of cytoplasmic processes.

Conclusion

UBA52P1 is a unique pseudogene that encodes a protein with a unique structure and function. Its expression and localization suggest that it may be involved in various cellular processes, including the transport of proteins between the cytoplasm and the ER, protein folding and quality control, and the regulation of cytoplasmic processes. The drug sensitivity and toxicity studies also suggest that UBA52P1 may be a potential drug target for various diseases characterized by protein misfolding. Additionally, UBA52P1 has the potential as a biomarker for various cellular processes. Further research is necessary to fully understand its functional role in various cellular processes and its potential as a drug target and biomarker.

Protein Name: Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 Pseudogene 1

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•   protein structure and compound binding;
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•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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