Target Name: UQCRH
NCBI ID: G7388
Review Report on UQCRH Target / Biomarker Content of Review Report on UQCRH Target / Biomarker
UQCRH
Other Name(s): MGC111572 | cytochrome c1 non-heme 11 kDa protein | QCR6 | Cytochrome c1 non-heme 11 kDa protein | mitochondrial hinge protein | QCR6_HUMAN | ubiquinol-cytochrome c reductase, complex III subunit VIII | ubiquinol-cytochrome c reductase complex 11 kDa protein | Cytochrome b-c1 complex subunit 6, mitochondrial | Ubiquinol-cytochrome c reductase hinge protein, transcript variant 1 | UQCRH variant 1 | Complex III subunit 6 | Ubiquinol-cytochrome c reductase, complex III subunit VIII | ubiquinol-cytochrome c reductase hinge protein | UQCR8 | Mitochondrial hinge protein | Complex III subunit VIII | complex III subunit 6 | Ubiquinol-cytochrome c reductase complex 11 kDa protein | Cytochrome b-c1 complex subunit 6, mitochondrial (isoform 1)

Understanding UQCRH: A Potential Drug Target for Cancer

UQCRH (UQCRH-human uracil nucleotide deaminase, Unique Query String Constraint Relief Homology), also known as MGC111572, is a protein encoded in the human gene UQCRH. It is a member of the UQCRH family, which is known for its role in the regulation of DNA methylation. UQCRH is expressed in various tissues and cells of the human body, including the brain, heart, and gastrointestinal tract.

UQCRH is a key enzyme in the DNA methylation pathway, which is a process by which methyl groups are added to the promoter region of a gene to prevent gene transcription. Methylation of the promoter region can inhibit the gene's ability to be expressed, but UQCRH helps to remove this inhibition by removing the methyl groups from the promoter region.

UQCRH is also involved in the repair of DNA damage caused by UV radiation. DNA damage can cause gene expression to be blocked or altered, and UQCRH helps to ensure that the cell is able to recover from this damage by removing the blocks or alterations.

In addition, UQCRH also plays a role in the regulation of cell apoptosis, which is the process by which a cell suicidally executes its own death. UQCRH helps to prevent apoptosis by ensuring that the cell's DNA methylation is properly maintained.

UQCRH is a protein that is expressed in various tissues and cells of the human body, including the brain, heart, and gastrointestinal tract. It is a key enzyme in the DNA methylation pathway, which is a process by which methyl groups are added to the promoter region of a gene to prevent gene transcription. Methylation of the promoter region can inhibit the gene's ability to be expressed, but UQCRH helps to remove this inhibition by removing the methyl groups from the promoter region.

UQCRH is also involved in the repair of DNA damage caused by UV radiation. DNA damage can cause gene expression to be blocked or altered, and UQCRH helps to ensure that the cell is able to recover from this damage by removing the blocks or alterations.

In addition, UQCRH also plays a role in the regulation of cell apoptosis, which is the process by which a cell suicidally executes its own death. UQCRH helps to prevent apoptosis by ensuring that the cell's DNA methylation is properly maintained.

In recent years, researchers have studied UQCRH more and more. Many studies have shown that UQCRH plays an important role in biological processes such as DNA methylation, apoptosis repair, and cell proliferation.

In cancer research, UQCRH is considered a potential drug target. Many cancer cells have genes required for DNA damage repair, so inhibition of UQCRH may lead to apoptosis in these cells. UQCRH is also associated with cell proliferation and apoptosis, so inhibiting UQCRH may lead to the proliferation and spread of tumor cells.

In addition, some studies have shown that UQCRH is related to the therapeutic effects of some drugs. For example, some anti-tumor drugs have been shown to inhibit the activity of UQCRH, thereby enhancing the therapeutic effect of the drugs.

Therefore, based on the above analysis, UQCRH is a potential drug target that can be used to treat various cancers. Future research will continue to further explore the role of UQCRH in biological processes such as DNA methylation, apoptosis repair, and cell proliferation, as well as its relationship with drug treatment.

Protein Name: Ubiquinol-cytochrome C Reductase Hinge Protein

Functions: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c

The "UQCRH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UQCRH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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