Target Name: USP37
NCBI ID: G57695
Review Report on USP37 Target / Biomarker Content of Review Report on USP37 Target / Biomarker
USP37
Other Name(s): MGC117261 | ubiquitin thioesterase 37 | UBP37_HUMAN | ubiquitin thiolesterase 37 | Ubiquitin thioesterase 37 | ubiquitin specific protease 37 | KIAA1594 | ubiquitin specific peptidase 37 | Ubiquitin thiolesterase 37 | Ubiquitin specific peptidase 37 | Ubiquitin carboxyl-terminal hydrolase 37 | Ubiquitin-specific processing protease 37 | ubiquitin-specific-processing protease 37 | Ubiquitin-specific-processing protease 37 | tmp_locus_50 | deubiquitinating enzyme 37 | Deubiquitinating enzyme 37

USP37: Regulating Cell Signaling, Apoptosis and Inflammation

USP37 (MGC117261) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a member of the USP family of proteins, which are known for their role in cell signaling and division . USP37 has been shown to play a role in the regulation of cell growth, apoptosis (programmed cell death), and inflammation.

One of the key functions of USP37 is its role in cell signaling. USP37 has been shown to interact with various signaling pathways, including the PI3K/Akt signaling pathway, TGF-β signaling pathway, and NF-kappa-B signaling pathway. These signaling pathways are Involved in a wide range of cellular processes, including cell growth, differentiation, migration, and inflammation.

In addition to its role in cell signaling, USP37 has also been shown to play a key role in the regulation of cell apoptosis. Apoptosis is a natural process that is involved in the removal of damaged or dysfunctional cells from the body. to play a role in the regulation of apoptosis by promoting the production of pro-apoptotic (apoptotic) factors and inhibiting the production of anti-apoptotic (apoptotic) factors.

Another function of USP37 is its role in the regulation of inflammation. USP37 has been shown to play a role in the regulation of inflammation by promoting the production of pro-inflammatory (cytokine) factors and inhibiting the production of anti-inflammatory (cytokine) ) factors. These factors are involved in the recruitment of immune cells to the site of inflammation and the regulation of their activity.

USP37 has also been shown to play a role in the regulation of cell division. USP37 has been shown to interact with the protein Brc1, which is involved in the regulation of DNA replication and cell division. These interactions may have implications for the regulation of cancer cell division.

In conclusion, USP37 is a protein that has been shown to play a role in the regulation of cell signaling, apoptosis, inflammation, and cell division. These functions make USP37 an attractive target for drug development. Further research is needed to fully understand the role of USP37 in these processes and to develop effective therapies.

Protein Name: Ubiquitin Specific Peptidase 37

Functions: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872)

The "USP37 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP37 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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