Target Name: USB1
NCBI ID: G79650
Review Report on USB1 Target / Biomarker Content of Review Report on USB1 Target / Biomarker
USB1
Other Name(s): U6 snRNA phosphodiesterase 1 (isoform 1) | mutated in PN protein 1 | U6 snRNA biogenesis phosphodiesterase 1 | 3'-5' RNA exonuclease USB1 | putative U6 snRNA phosphodiesterase | HVSL motif containing

USB1: A Potential Drug Target and Biomarker for Many Diseases

USB1, or U6 snRNA phosphodiesterase 1 (isoform 1), is a protein that plays a crucial role in the regulation of gene expression in the cell. It is a key enzyme in the U6 snRNA complex, which is responsible for modifying the stability and translation efficiency of U6 snRNAs, a type of RNA molecule that plays a central role in post-transcriptional gene regulation.

USB1 functions as a phosphodiesterase, breaking down a covalent phosphate bond between the 5' end of a U6 snRNA and its 3' end. This modification can have a significant impact on the stability and translation efficiency of the U6 snRNA, allowing it to either translocate into the cytoplasm or the endoplasmic reticulum for degradation.

USB1 is a protein that is expressed in most tissues and cells, and it is involved in a wide range of cellular processes, including cell growth, apoptosis, and transcriptional regulation. It is a key regulator of gene expression, and is involved in the regulation of many different genes, including those that are involved in cell adhesion, migration, and survival.

In addition to its role in gene regulation, USB1 is also a potential drug target. Its role in the regulation of U6 snRNA modification has been implicated in the development and progression of many different diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the potential advantages of USB1 as a drug target is its relatively simple structure. USB1 is a small protein that is expressed in most tissues and cells, which makes it relatively easy to target and manipulate. Additionally, its role in the regulation of gene expression makes it a potentially attractive target for small molecules, which are often effective in drug development.

Another advantage of USB1 is its ability to act as a negative regulator. USB1 can inhibit the activity of other enzymes that are involved in the regulation of gene expression, which can potentially make it a useful drug target for diseases where excessive or unnecessary regulation of gene expression is thought to be a contributing factor.

In addition to its potential as a drug target, USB1 is also a potential biomarker. Its role in the regulation of U6 snRNA modification has been implicated in the development and progression of many different diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. By measuring the levels of USB1 in different tissues and cells, researchers may be able to gain insights into the underlying mechanisms of these diseases and identify potential new treatments.

Overall, USB1 is a protein that plays a crucial role in the regulation of gene expression in the cell. Its role in the U6 snRNA complex makes it a potential drug target and a potential biomarker for a wide range of diseases. Further research is needed to fully understand its mechanisms of action and its potential as a therapeutic agent.

Protein Name: U6 SnRNA Biogenesis Phosphodiesterase 1

Functions: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753). In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367)

The "USB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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USE1 | USF1 | USF2 | USF3 | USH1C | USH1G | USH2A | USHBP1 | USO1 | USP1 | USP1-UAF1 complex | USP10 | USP11 | USP12 | USP12-AS1 | USP12-DT | USP13 | USP14 | USP15 | USP16 | USP17L1 | USP17L10 | USP17L11 | USP17L12 | USP17L13 | USP17L14P | USP17L15 | USP17L17 | USP17L18 | USP17L2 | USP17L20 | USP17L21 | USP17L24 | USP17L25 | USP17L26 | USP17L27 | USP17L29 | USP17L3 | USP17L5 | USP17L6P | USP17L7 | USP17L8 | USP17L9P | USP18 | USP19 | USP2 | USP2-AS1 | USP20 | USP21 | USP22 | USP24 | USP25 | USP26 | USP27X | USP27X-DT | USP28 | USP29 | USP3 | USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST