USP46: A Protein in Cell Signaling, Degradation, DNA Replication and Repair and Cell Adhesion

Target Name: USP46

NCBI ID: G64854

USP46

USP46: A Protein in Cell Signaling, Degradation, DNA Replication and Repair and Cell Adhesion

USP46, also known as Ubiquitin Specific Peptidase 46, is a protein that is expressed in a variety of cell types throughout the body. It is a member of the ubiquitin protein family, which is a group of enzymes that remove a ubiquitin tag from a protein target. USP46 is specific for the protein Ubiquitin, which is a key component of the ubiquitin-proteasome system.

USP46 plays a critical role in the regulation of protein degradation and cell signaling. It is involved in the degradation of various proteins, including Ubiquitin, which is a key component of the ubiquitin-proteasome system. When Ubiquitin is phosphorylated and targeted for degradation, USP46 removes the ubiquitin tag, allowing it to be processed and eliminated from the cell.

USP46 is also involved in the regulation of cell signaling pathways. It has been shown to be involved in the degradation of signaling proteins that play important roles in cell signaling, such as serpins andRepository protein. This suggests that USP46 may be a drug target or biomarker for diseases that are characterized by the over-expression or dysfunction of these signaling proteins.

In addition to its role in protein degradation, USP46 is also involved in the regulation of DNA replication and repair. It has been shown to be involved in the degradation of the protein DnaJ, which is required for the proper functioning of the DNA replication machinery. This suggests that USP46 may be a drug target or biomarker for diseases that are characterized by the over-expression or dysfunction of genes involved in DNA replication and repair.

USP46 is also involved in the regulation of cell adhesion and migration. It has been shown to be involved in the degradation of the protein vimentin, which is involved in the formation of tight junctions and adherens junctions, which are important for cell adhesion and migration. This suggests that USP46 may be a drug target or biomarker for diseases that are characterized by the over-expression or dysfunction of genes involved in cell adhesion and migration.

In conclusion, USP46 is a protein that is involved in the regulation of protein degradation, cell signaling pathways, DNA replication and repair, and cell adhesion and migration. It is a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of USP46 in these processes and to develop effective treatments for diseases that are characterized by its dysfunction.

Protein Name: Ubiquitin Specific Peptidase 46

Functions: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014)

The "USP46 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP46 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets