Target Name: URB1
NCBI ID: G9875
Review Report on URB1 Target / Biomarker Content of Review Report on URB1 Target / Biomarker
URB1
Other Name(s): NPA1 | nucleolar preribosomal-associated protein 1 | Nucleolar preribosomal-associated protein 1 | Nucleolar pre-ribosomal-associated protein 1 | nucleolar protein 254 kDa | URB1 ribosome biogenesis 1 homolog | URB1 ribosome biogenesis homolog | Nucleolar protein 254 kDa | KIAA0539 | NOP254 | NPA1P_HUMAN | C21orf108

URB1: A Potential Drug Target and Biomarker for Various Diseases

URB1 (NPA1), a protein located in the endoplasmic reticulum, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. Its unique structure and function have made it an attractive target for researchers to study and develop new treatments.

URB1 is a 24-kDa protein that is expressed in most tissues and cells in the body. It is composed of two major domains: a N-terminal transmembrane domain and a C-terminal cytoplasmic domain. The N-terminal domain is rich in conserved hypothetical transmembrane potential (HTP) domains, which are known to play a crucial role in protein signaling and interactions. The C-terminal domain contains a unique farnesylated cysteine residue, which is a hallmark of the endoplasmic reticulum and is involved in protein folding and localization.

URB1 has been shown to play a key role in various cellular processes, including cell signaling, protein folding, and modulating the expression of other genes. One of its most well-documented functions is its role in modulating the activity of the protein tyrosine kinase (TKG), which is involved in a wide range of cellular processes, including cell signaling, DNA replication, and metabolism.

URB1 has been shown to interact with TKG and to play a role in the regulation of TKG activity. This interaction between URB1 and TKG has led to the speculation that URB1 may be a drug target for TKG-related diseases.

In addition to its role in modulating TKG activity, URB1 has also been shown to play a role in the regulation of other cellular processes, including cell adhesion, migration, and the regulation of the cytoskeleton. It has been shown to interact with several other proteins, including the transcription factor PDGF-尾 and the protein kinase B-cell src (BCS) kinase.

URB1 has also been shown to be involved in the regulation of cellular metabolism and homeostasis. It has been shown to interact with the protein NHEJ, which is involved in DNA repair and metabolism, and to regulate the activity of the protein p53, which is involved in the regulation of DNA damage repair.

In addition to its role in modulating cellular processes, URB1 has also been shown to play a role in the development and progression of various diseases. For example, URB1 has been shown to be involved in the development of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. It has also been shown to be involved in the development of cancer, including breast and ovarian cancer.

URB1's unique structure and function make it an attractive target for researchers to study and develop new treatments. Its role in modulating TKG activity and its involvement in the regulation of various cellular processes make it a potential drug target for TKG-related diseases. Its role in modulating cellular metabolism and homeostasis make it a potential target for diseases that are characterized by disruptions in cellular homeostasis. Its involvement in the development and progression of various diseases make it a potential candidate for cancer and neurodegenerative disorder therapies.

In conclusion, URB1 is a protein that has the potential to be a drug target and biomarker for a wide range of diseases. Its unique structure and function make it an attractive target for researchers to study and develop new treatments. Further research is needed to fully understand its role in cellular processes and its potential as a drug target.

Protein Name: URB1 Ribosome Biogenesis Homolog

The "URB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about URB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

URB1-AS1 | URB2 | Urea transporter | URGCP | URGCP-MRPS24 | URI1 | Uridine phosphorylase | URM1 | UROC1 | UROD | UROS | USB1 | USE1 | USF1 | USF2 | USF3 | USH1C | USH1G | USH2A | USHBP1 | USO1 | USP1 | USP1-UAF1 complex | USP10 | USP11 | USP12 | USP12-AS1 | USP12-DT | USP13 | USP14 | USP15 | USP16 | USP17L1 | USP17L10 | USP17L11 | USP17L12 | USP17L13 | USP17L14P | USP17L15 | USP17L17 | USP17L18 | USP17L2 | USP17L20 | USP17L21 | USP17L24 | USP17L25 | USP17L26 | USP17L27 | USP17L29 | USP17L3 | USP17L5 | USP17L6P | USP17L7 | USP17L8 | USP17L9P | USP18 | USP19 | USP2 | USP2-AS1 | USP20 | USP21 | USP22 | USP24 | USP25 | USP26 | USP27X | USP27X-DT | USP28 | USP29 | USP3 | USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51