Target Name: USP4
NCBI ID: G7375
Review Report on USP4 Target / Biomarker Content of Review Report on USP4 Target / Biomarker
USP4
Other Name(s): USP4 variant 1 | Ubiquitin carboxyl-terminal hydrolase 4 (isoform a) | ubiquitous nuclear protein homolog | Ubiquitin carboxyl-terminal esterase 4 | ubiquitin carboxyl-terminal esterase 4 | Ubiquitin thiolesterase 4 | Ubiquitin-specific processing protease 4 | MGC149848 | ubiquitin thioesterase 4 | MGC149849 | Unph | Ubiquitin thioesterase 4 | Deubiquitinating enzyme 4 | UNPH | deubiquitinating enzyme 4 | UBP4_HUMAN | Ubiquitin specific peptidase 4, transcript variant 1 | ubiquitin-specific processing protease 4 | UNP | Ubiquitin-specific-processing protease 4 | ubiquitin specific protease 4 (proto-oncogene) | ubiquitin thiolesterase 4 | Ubiquitin specific protease 4 | Ubiquitous nuclear protein homolog | Ubiquitin carboxyl-terminal hydrolase 4 | ubiquitin specific peptidase 4 (proto-oncogene) | Ubiquitin specific protease 4 (proto-oncogene) | ubiquitin specific peptidase 4 | Sjoegren syndrome nuclear autoantigen 1 homolog

USP4: A Potential Drug Target Or Biomarker

USP4, also known as USP4 variant 1, is a protein that is expressed in various tissues throughout the body. It is a member of the USP4 gene family, which is known for its role in cell signaling and division. USP4 has been identified as a potential drug target or biomarker, and research is being conducted to investigate its potential utility as a therapeutic agent.

The USP4 gene family is characterized by the presence of a unique N-terminal transmembrane domain and a unique C-terminal cytoplasmic domain. The N-terminal transmembrane domain is known as the USP4-1 domain and is responsible for the protein's transmembrane properties. C-terminal cytoplasmic domain is known as the USP4-2 domain and is responsible for the protein's cytoplasmic localization.

USP4 is a protein that is expressed in a variety of tissues throughout the body, including the brain, pancreas, and heart. It is involved in the regulation of cell signaling and division, and is thought to play a role in the development and progression of various diseases.

One of the key functions of USP4 is its role in the regulation of cell division. USP4 is a member of the spindle-tubulin family, which is responsible for the formation and maintenance of the microtubules that organize the mitotic spindle. USP4 is thought to play a role in the regulation of microtubule dynamics and stability, and is thus considered to be a potential drug target or biomarker for diseases that are characterized by disruptions in cell division.

In addition to its role in cell division, USP4 is also involved in the regulation of cell signaling. It is a member of the PDZ/PIP signaling pathway, which is a network of proteins that communicate through the interaction of phosphatidylinositol (PA) and inositol (IN) signals. USP4 is thought to play a role in the regulation of the growth and differentiation of various tissues, and is thus considered to be a potential drug target or biomarker for diseases that are characterized by disruptions in cell signaling.

USP4 has also been identified as a potential drug target or biomarker for a variety of other diseases. For example, USP4 has been shown to be involved in the development and progression of various types of cancer, including breast, ovarian, and colorectal cancer. It is also thought to play a role in the regulation of inflammation and autoimmune diseases, and is thus considered to be a potential biomarker for these types of diseases.

In conclusion, USP4 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of cell signaling and division. It is thought to play a role in the development and progression of various diseases, and is thus considered to be a potential drug target or biomarker. Further research is being conducted to investigate its potential utility as a therapeutic agent, and results are promising.

Protein Name: Ubiquitin Specific Peptidase 4

Functions: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847)

The "USP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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