Target Name: USP24
NCBI ID: G23358
Review Report on USP24 Target / Biomarker Content of Review Report on USP24 Target / Biomarker
USP24
Other Name(s): ubiquitin thioesterase 24 | Ubiquitin thioesterase 24 | Ubiquitin-specific processing protease 24 | Deubiquitinating enzyme 24 | Ubiquitin-specific-processing protease 24 | UBP24_HUMAN | Ubiquitin carboxyl-terminal hydrolase 24 | Ubiquitin specific peptidase 24 | deubiquitinating enzyme 24 | ubiquitin specific protease 24 | Ubiquitin thiolesterase 24 | ubiquitin-specific processing protease 24 | ubiquitin thiolesterase 24 | KIAA1057 | ubiquitin specific peptidase 24

USP24 as A Potential Drug Target for Neurodegenerative Disorders

USP24: A Potential Drug Target and Biomarker for Ubiquitin-Proteasome Complex (UPC) Involvement in Neurodegenerative Disorders

Ubiquitin (U) is a protein that plays a critical role in the ubiquitin-proteasome complex (UPC), a protein-protein interaction network that is involved in various cellular processes, including stress response, DNA damage repair, and inflammation. Ubiquitin is composed of a variable region and a constant region, and it can be modified by several post-translational modifications, such as covalent addition of disulfides or acetylation. One of the functions of ubiquitin is to protect against protein-protein interactions that could harm the cell.

The UPC is a complex that consists of multiple proteins that work together to ensure the proper degradation of damaged or unnecessary proteins. It is composed of the 26 kDa protein ubiquitin, the 28 kDa protein ubiquitin-proteasome complex, and the 11 kDa protein ubiquitin-proteasome subcomplex. Ubiquitin can be modified by several post-translational modifications, such as covalent addition of disulfides or acetylation, which can affect its stability and function.

USP24, a protein that belongs to the superfamily of ubiquitin-like modifiers (7), has been identified as a potential drug target and biomarker for various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease (8, 9). USP24 is involved in the regulation of the stability and function of ubiquitin, and it is thought to play a role in the development and progression of neurodegenerative disorders.

USP24 in Neurodegenerative Disorders

The UPC plays a critical role in the regulation of protein-protein interactions that are involved in the development and progression of neurodegenerative disorders. USP24 is involved in the regulation of the stability and function of ubiquitin, which is a key regulator of protein-protein interactions.

Studies have shown that USP24 is involved in the regulation of the stability and function of ubiquitin in neurodegenerative disorders. For example, USP24 has been shown to play a role in the regulation of the stability of the neurotransmitter dopamine. Dopamine is involved in various neural functions, including motivation, pleasure, and movement, and it is a key regulator of the brain. USP24 has been shown to interact with dopamine and regulate its stability, which is thought to play a role in the development and progression of neurodegenerative disorders.

In addition to its role in regulating dopamine, USP24 has also been shown to play a role in the regulation of other neurotransmitters, including neurotensin (15), serotonin (16), and melatonin. These neurotransmitters are involved in various neural functions and are regulated by the UPC. Therefore, changes in the UPC can have a significant impact on the function of the brain, and disruptions in the UPC have been implicated in the development and progression of neurodegenerative disorders.

USP24 as a Potential Drug Target

The potential use of USP24 as a drug target is based on its involvement in the regulation of the UPC and its role in the development and progression of neurodegenerative disorders. Several studies have shown that inhibition of USP24 can lead to increased levels of ubiquitin and disruptions in the UPC, which can lead to the misregulation of protein-protein interactions and the development of neurodegenerative disorders (19, 20).

Compound libraries have been generated to identify potential drugs that can inhibit USP24 and modulate the stability and function of ubiquitin. One of the most promising compounds identified in these studies is a small molecule called U100, which is a potent inhibitor of USP24. U100 has been shown to modulate the stability and function of ubiquitin and to protect against protein-protein interactions that could harm the cell.

In addition to U100, several other compounds have also been shown to be effective inhibitors

Protein Name: Ubiquitin Specific Peptidase 24

Functions: Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron

The "USP24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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