Target Name: USP3
NCBI ID: G9960
Review Report on USP3 Target / Biomarker Content of Review Report on USP3 Target / Biomarker
USP3
Other Name(s): UBP | MGC129879 | Ubiquitin thioesterase 3 | Ubiquitin-specific-processing protease 3 | ubiquitin thiolesterase 3 | Ubiquitin carboxyl-terminal hydrolase 3 | ubiquitin specific peptidase 3 | SIH003 | Ubiquitin specific peptidase 3, transcript variant 1 | UBP3_HUMAN | Deubiquitinating enzyme 3 | USP3 variant 1 | Ubiquitin specific protease 3 | MGC129878 | Ubiquitin thiolesterase 3 | ubiquitin-specific-processing protease 3 | Ubiquitin carboxyl-terminal hydrolase 3 (isoform 1) | deubiquitinating enzyme 3 | ubiquitin thioesterase 3

USP3: Key Regulator of Proteasome System and Cell Signaling

USP3 (Ubiquitin-Proteasome Interface) is a protein that plays a crucial role in the regulation of protein degradation in the cell. It is a key player in the ubiquitin-proteasome system (UPS), which is responsible for breaking down damaged or unnecessary proteins . USP3 is a protein that is expressed in almost all cell types and is involved in the process of protein degradation by the ubiquitin-proteasome system.

USP3 is a 21-kDa protein that is composed of two structural subunits: a 194-kDa alpha subunit and a 16-kDa beta subunit. The alpha subunit consists of a variable region that includes a nucleotide-binding oligomerization domain (NBO), a conserved protein-coding region, and a C-terminal region that is involved in the formation of a N-terminal pocket. The beta subunit consists of a variable region that includes a nucleotide-binding oligomerization domain (NBO), a conserved protein-coding region, and a C-terminal region that is involved in the formation of a N-terminal pocket.

USP3 is a key protein that is involved in the regulation of protein degradation by the ubiquitin-proteasome system. It is a critical regulator of the ubiquitin-proteasome system because it helps to ensure that only functional proteins are released from the endoplasmic reticulum (ER) and that damaged or unnecessary proteins are properly degraded.

One of the key functions of USP3 is its role in the regulation of the ubiquitin-proteasome system. USP3 helps to ensure that only functional proteins are released from the ER and that damaged or unnecessary proteins are properly degraded. It does this by participating in the formation of the ubiquitin bond between the amino acids that make up the protein and the ubiquitin protein itself.

USP3 is also involved in the regulation of protein stability and cell signaling. It helps to ensure that proteins that are important for cell signaling are retained in the ER and that they are not released unless they are needed. This helps to ensure that cells are able to maintain the right balance of signaling proteins and non-signaling proteins.

In addition to its role in the regulation of protein degradation and stability, USP3 is also involved in the regulation of protein interactions. It helps to ensure that proteins that are important for cell signaling are able to interact with each other and that these interactions are properly regulated.

Overall, USP3 is a protein that plays a crucial role in the regulation of protein degradation and stability in the cell. It is a key player in the ubiquitin-proteasome system and is involved in the regulation of protein interactions, as well as the regulation of protein stability and cell signaling. As a result, USP3 is an attractive drug target and may be useful for the development of new treatments for a variety of diseases.

Protein Name: Ubiquitin Specific Peptidase 3

Functions: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin

The "USP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST | UTF1 | UTP11 | UTP14A | UTP14C | UTP15 | UTP18 | UTP20 | UTP23 | UTP25 | UTP3 | UTP4 | UTP6 | UTRN | UTS2 | UTS2B | UTS2R | UTY | UVRAG | UVSSA | UXS1 | UXT | UXT-AS1 | VAC14 | Vacuolar H+ ATPase | VAMP1 | VAMP2 | VAMP3 | VAMP4 | VAMP5 | VAMP7 | VAMP8 | VANGL1 | VANGL2 | VAPA | VAPB | VARS1 | VARS2 | Vascular endothelial growth factor receptor (VEGFR) | Vascular endothelial growth factors (VEGF) | VASH1 | VASH1-AS1 | VASH2 | VASN | Vasoactive intestinal polypeptide receptor (VIP-R) | Vasohibin | Vasopressin Receptor | Vasopressin V1 Receptor | VASP | VAT1 | VAT1L | VAV1 | VAV2 | VAV3 | VAV3-AS1 | VAX1 | VAX2 | VBP1 | VCAM1