Target Name: USH1C
NCBI ID: G10083
Review Report on USH1C Target / Biomarker Content of Review Report on USH1C Target / Biomarker
USH1C
Other Name(s): Harmonin | Antigen NY-CO-38/NY-CO-37 | truncated Usher syndrome typeIC | USH1 protein network component harmonin, transcript variant 1 | renal carcinoma antigen NY-REN-3 | PDZD7C | PDZ-73 | Harmonin (isoform a) | USH1C_HUMAN | autoimmune enteropathy-related antigen AIE-75 | USH1 protein network component harmonin, transcript variant b3 | DFNB18 | Ush1cpst | Harmonin (isoform b3) | DFNB18A | USH1 protein network component harmonin | Autoimmune enteropathy-related antigen AIE-75 | NY-CO-38 | AIE-75 | USH1C variant 1 | Renal carcinoma antigen NY-REN-3 | usher syndrome type-1C protein | PDZ-45 | Protein PDZ-73 | PDZ-73/NY-CO-38 | PDZ73 | USH1C variant b3 | NY-CO-37 | ush1cpst | Usher syndrome type-1C protein | antigen NY-CO-38/NY-CO-37 | Usher syndrome 1C (autosomal recessive, severe) | AIE75

USH1C: The Potential Drug Target and Biomarker for Parkinson's Disease

Parkinson's disease is a neurodegenerative disorder that affects the quality of life of millions of people worldwide. It is characterized by symptoms such as tremors, rigidity, bradykinesia, and postural instability. The exact cause of Parkinson's disease is not known, but it is thought to involve the neurotransmitter dopamine. USH1C, a protein that is expressed in the brain, has been identified as a potential drug target and biomarker for Parkinson's disease.

The USH1C gene is located on chromosome 12q34 and encodes a protein that is expressed in the brain. The protein is composed of 194 amino acids and has a calculated molecular weight of 21 kDa. USH1C is a protein that is expressed in the brain and is involved in the formation of the endoplasmic reticulum. It is also involved in the regulation of protein synthesis and in the detoxification of harmful substances.

Parkinson's disease is a neurodegenerative disorder that is characterized by symptoms such as tremors, rigidity, bradykinesia, and postural instability. The exact cause of Parkinson's disease is not known, but it is thought to involve the neurotransmitter dopamine. The neurotransmitter dopamine is involved in the regulation of motor movement and is thought to be abnormal in individuals with Parkinson's disease.

Research has identified USH1C as a potential drug target for Parkinson's disease. The protein is expressed in the brain and is involved in the formation of the endoplasmic reticulum, which is the site where proteins are synthesized and degraded. It is also involved in the regulation of protein synthesis and in the detoxification of harmful substances.

In addition, USH1C has been shown to be involved in the regulation of dopamine levels in the brain. Dopamine is a neurotransmitter that is involved in the regulation of motor movement and is thought to be abnormal in individuals with Parkinson's disease. Studies have shown that USH1C plays a role in the regulation of dopamine levels in the brain and that it is involved in the detoxification of dopamine-related compounds.

Furthermore, USH1C has been shown to be involved in the regulation of neurotransmitter levels in the brain. Neurotransmitters are chemical messengers that are involved in the communication of neurons in the brain. Studies have shown that USH1C plays a role in the regulation of neurotransmitter levels in the brain and that it is involved in the detoxification of harmful substances.

In conclusion, USH1C is a protein that is expressed in the brain and is involved in the formation of the endoplasmic reticulum, the regulation of protein synthesis, and the detoxification of harmful substances. Furthermore, USH1C has been shown to be involved in the regulation of dopamine levels in the brain and has been identified as a potential drug target for Parkinson's disease. Further research is needed to determine the exact role of USH1C in Parkinson's disease and to develop effective treatments.

Protein Name: USH1 Protein Network Component Harmonin

Functions: Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018)

The "USH1C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USH1C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

USH1G | USH2A | USHBP1 | USO1 | USP1 | USP1-UAF1 complex | USP10 | USP11 | USP12 | USP12-AS1 | USP12-DT | USP13 | USP14 | USP15 | USP16 | USP17L1 | USP17L10 | USP17L11 | USP17L12 | USP17L13 | USP17L14P | USP17L15 | USP17L17 | USP17L18 | USP17L2 | USP17L20 | USP17L21 | USP17L24 | USP17L25 | USP17L26 | USP17L27 | USP17L29 | USP17L3 | USP17L5 | USP17L6P | USP17L7 | USP17L8 | USP17L9P | USP18 | USP19 | USP2 | USP2-AS1 | USP20 | USP21 | USP22 | USP24 | USP25 | USP26 | USP27X | USP27X-DT | USP28 | USP29 | USP3 | USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST | UTF1 | UTP11 | UTP14A | UTP14C | UTP15