Target Name: USP14
NCBI ID: G9097
Review Report on USP14 Target / Biomarker Content of Review Report on USP14 Target / Biomarker
USP14
Other Name(s): UBP14_HUMAN | TGT | tRNA-guanine transglycosylase, 60-kD subunit | Ubiquitin-specific-processing protease 14 | ubiquitin thiolesterase 14 | ubiquitin specific protease 14 (tRNA-guanine transglycosylase) | Ubiquitin specific protease 14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | ubiquitin specific peptidase 14 | Ubp6 | Ubiquitin carboxyl-terminal hydrolase 14 (isoform a) | Ubiquitin thioesterase 14 | Ubiquitin carboxyl-terminal hydrolase 14 | Ubiquitin specific peptidase 14, transcript variant 1 | ubiquitin-specific processing protease 14 | deubiquitinating enzyme 14 | ubiquitin thioesterase 14 | Ubiquitin specific protease 14 (tRNA-guanine transglycosylase) | USP14 variant 1 | Deubiquitinating enzyme 14 | Ubiquitin thiolesterase 14

USP14: Potential Drug Targets Or Biomarkers for Diseases

USP14 (Usp14) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and pancreas. It is a member of the Usp family of proteins, which are involved in various cellular processes, including cell signaling, DNA repair, and metabolism. USP14 has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Usp family of proteins plays a crucial role in the regulation of cellular processes that are essential for the survival of all living organisms. The proteins in this family are involved in the maintenance of DNA integrity, the repair of damaged DNA, and the regulation of metabolism. USP14 is a member of the Usp family that is involved in the regulation of DNA repair.

DNA repair is a critical process that is essential for the maintenance of genetic integrity. When DNA is damaged or mutated, it can lead to the development of various diseases, including cancer. USP14 is involved in the regulation of DNA repair, which is critical for the maintenance of cellular health and the prevention of diseases.

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the progressive loss of brain cells and the development of various symptoms. These diseases are caused by the accumulation of damaged DNA in the brain, which leads to the progressive loss of cellular health and the development of the disease symptoms. USP14 has been identified as a potential drug target or biomarker for these diseases, as it has been shown to play a role in the regulation of DNA repair in the brain.

Autoimmune disorders, such as rheumatoid arthritis, lupus, and multiple sclerosis, are characterized by the immune system attacking the body's own tissues, leading to inflammation and various symptoms. These disorders are caused by the immune system becoming hyperactive and causing inflammation in the body. USP14 has been shown to play a role in the regulation of immune system function, which is critical for the prevention of autoimmune disorders.

In conclusion, USP14 is a protein that is expressed in various tissues of the human body and is involved in the regulation of DNA repair, which is critical for the maintenance of cellular health and the prevention of diseases. USP14 has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to determine the role of USP14 in the regulation of cellular processes and the development of diseases.

Protein Name: Ubiquitin Specific Peptidase 14

Functions: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593)

The "USP14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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USP15 | USP16 | USP17L1 | USP17L10 | USP17L11 | USP17L12 | USP17L13 | USP17L14P | USP17L15 | USP17L17 | USP17L18 | USP17L2 | USP17L20 | USP17L21 | USP17L24 | USP17L25 | USP17L26 | USP17L27 | USP17L29 | USP17L3 | USP17L5 | USP17L6P | USP17L7 | USP17L8 | USP17L9P | USP18 | USP19 | USP2 | USP2-AS1 | USP20 | USP21 | USP22 | USP24 | USP25 | USP26 | USP27X | USP27X-DT | USP28 | USP29 | USP3 | USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST | UTF1 | UTP11 | UTP14A | UTP14C | UTP15 | UTP18 | UTP20 | UTP23 | UTP25 | UTP3 | UTP4 | UTP6 | UTRN | UTS2 | UTS2B | UTS2R | UTY | UVRAG