USP48: A Potential Drug Target and Biomarker for Ubiquitin-Specific Processing Protease 48

Target Name: USP48

NCBI ID: G84196

USP48

USP48: A Potential Drug Target and Biomarker for Ubiquitin-Specific Processing Protease 48

Introduction

Ubiquitin-specific processing protease 48 (USP48) is a protein that plays a crucial role in the regulation of protein degradation and quality control in the cell. It is a member of the ubiquitin-proteasome system (UPS), which is responsible for breakdown and Scavenge damaged or unnecessary proteins. The dysfunction of USP48 has been implicated in a variety of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. As a result, targeting USP48 has become an attractive research focus with the potential to develop new treatments for a range of diseases.

In this article, we will explore USP48 as a drug target and biomarker. We will discuss its structure, function, and the current research on its potential as a drug target. We will also examine the potential clinical applications of USP48-targeted therapies and the biomarkers that can be used to monitor their effectiveness.

Structure and Function

USP48 is a 23-kDa protein that is expressed in a variety of tissues, including the brain, pancreas, and heart. It is highly conserved, with a calculated pI of 6.9 and a predicted localization in the cytoplasm. USP48 is composed of a N -terminal alpha helix, a middle beta sheet, and a C-terminal tertiary structure domain. The middle beta sheet is the most conserved region of the protein and is involved in the formation of the N-endoproteasome, which is the site of protein degradation.

The function of USP48 is to regulate the degradation of damaged or unnecessary proteins. It does this by forming a covalent complex with the ubiquitin protein, which is then added to the N-endoproteasome for degradation. This process is critical for maintaining the protein homeostasis, as the degradation of proteins is involved in many cellular processes, including cell signaling, tissue repair, and inflammation.

USP48 has been shown to play a role in the regulation of several cellular processes, including cell signaling, angiogenesis, and neurodegeneration. For example, USP48 has been shown to be involved in the regulation of the Notch signaling pathway, which is involved in the development and maintenance of neural stem cells. It has also been shown to play a role in the regulation of the TGF-β pathway, which is involved in cell growth, angiogenesis, and tissue repair.

Potential Drug Targets

The USP48-targeted therapies have the potential to treat a variety of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. One of the main advantages of targeting USP48 is its targetedness, as it is involved in the regulation of a specific cellular process. This allows for the development of drugs that specifically target USP48 and can modulate its activity without affecting other cellular processes.

There are several potential drug targets for USP48, including inhibitors of the ubiquitin-proteasome system, modulators of the Notch signaling pathway, and inhibitors of the TGF-β pathway. In addition, USP48 has also been shown to play a role in the regulation of cell adhesion, which is involved in the development of cancer. Therefore, targeting USP48 may also have the potential to treat cancers, including breast, ovarian, and prostate cancers.

Biomarkers

Monitoring the effectiveness of USP48-targeted therapies is important for the development of new treatments for diseases. There are several biomarkers that can be used to monitor the effectiveness of these therapies.

Protein Name: Ubiquitin Specific Peptidase 48

Functions: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites

The "USP48 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP48 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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