USP51: A Potential Drug Target and Biomarker (G158880)

Target Name: USP51

NCBI ID: G158880

USP51

USP51: A Potential Drug Target and Biomarker

Ubiquitin thiolesterase 51 (USP51) is a protein that plays a critical role in the regulation of cellular processes. It is a member of the ubiquitin family of proteins, which are involved in a variety of cellular processes, including protein degradation and modulation. USP51 is a 21-kDa protein that is expressed in most tissues and cells in the body.

USP51 functions as a enzyme that removes a ubiquitin molecule from a target protein. This process is called ubiquitination, and it is a critical step in the regulation of protein function. Ubiquitination is a reversible covalent chemical reaction that involves the transfer of a ubiquitin molecule from a ubiquitin protein (also known as a pro-protein) to a target protein. This transfer of a ubiquitin molecule to a target protein can modulate the activity, stability, and localization of the target protein.

USP51 is involved in the regulation of many cellular processes, including cell division, apoptosis, and inflammation. It is a key player in the ubiquitin signaling pathway, which is involved in the regulation of protein function and cell survival. USP51 is also involved in the regulation of DNA replication and repair, as well as in the regulation of cell adhesion and migration.

In addition to its role in cellular signaling, USP51 has also been shown to be a potential drug target. Many drugs that are currently in use, such as ustekinumab and obeticholic acid, are designed to inhibit the activity of USP51. This is because USP51 is involved in the regulation of many cellular processes, and drugs that inhibit its activity can have a variety of therapeutic effects.

One of the potential benefits of targeting USP51 is its potential to treat a variety of diseases. Many diseases are caused by the overproduction or underproduction of specific proteins, and drugs that target USP51 have the potential to treat a wide range of conditions. For example, USP51 has been shown to be involved in the regulation of cancer cell growth and survival, and inhibiting its activity has been shown to have anti-tumor effects.

In addition to its potential therapeutic applications, USP51 is also a potential biomarker. Its role in the regulation of cellular processes makes it a useful tool for the study of protein function and the regulation of cellular processes. By measuring the levels of USP51 in different cellular contexts, researchers can gain insights into the mechanisms of protein regulation and the consequences of changes in protein levels.

Overall, USP51 is a protein that is involved in a variety of cellular processes and has the potential to be a drug target or biomarker. Its role in the regulation of protein function and cellular processes makes it an attractive target for researchers to study, and its potential therapeutic and biomarker applications make it a valuable tool for the development of new drugs.

Protein Name: Ubiquitin Specific Peptidase 51

Functions: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998)

The "USP51 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP51 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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