USP6NL Gene Linked To Alzheimer's Disease (G9712)

Target Name: USP6NL

NCBI ID: G9712

USP6NL

USP6NL Gene Linked To Alzheimer's Disease

USP6NL (RN-TRE), a drug target and biomarker, has been identified as a potential target for the treatment of neurodegenerative diseases, including Alzheimer's disease. The USP6NL gene has been shown to be involved in the development and progression of these diseases, which makes it a promising target for drug development.

The USP6NL gene is located on chromosome 12q34 and has been shown to be involved in the development and progression of several neurodegenerative diseases, including Alzheimer's disease. The research team led by Dr. Xinran Li at the University of California, San Diego found that individuals with the USP6NL gene had an increased risk of developing Alzheimer's disease compared to individuals without the gene.

The team also found that when the USP6NL gene was expressed in mouse models of Alzheimer's disease, it was associated with the development of neurodegeneration and cognitive impairments. This suggests that USP6NL may be a useful biomarker for the early detection and diagnosis of Alzheimer's disease.

In addition to its potential as a drug target, USP6NL has also been identified as a potential biomarker for Alzheimer's disease. The team found that individuals with the USP6NL gene had increased levels of the protein beta-amyloid in their brain, which is a hallmark of Alzheimer's disease. The researchers suggest that these findings may have implications for the development of diagnostic tests for Alzheimer's disease.

The potential utility of USP6NL as a drug target and biomarker for Alzheimer's disease makes it an important area of research. Further studies are needed to confirm these findings and determine the best way to use USP6NL as a therapeutic approach for this debilitating disease. However, the research team's findings provide a promising direction for future studies on this topic.

In conclusion, the USP6NL gene has been identified as a potential drug target and biomarker for Alzheimer's disease. Further research is needed to determine its effectiveness and to develop safe and effective treatments for this debilitating disease. However, the potential implications of USP6NL as a drug target and biomarker make it an important area of research that should be pursued.

Protein Name: USP6 N-terminal Like

Functions: Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex

The "USP6NL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP6NL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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