USP9X: A Potential Drug Target and Biomarker (G8239)

Target Name: USP9X

NCBI ID: G8239

USP9X

USP9X: A Potential Drug Target and Biomarker

USP9X is a protein that is expressed in nearly all cell types, including neurons, muscle cells, and blood cells. It is a member of the ubiquitin system, a protein degradation pathway that is essential for cell signaling and division. Ubiquitin plays a crucial role in regulating protein stability and stability-dependent processes, and is involved in a wide range of cellular processes, including cell division, cell signaling, and inflammation.

In recent years, researchers have identified numerous potential drug targets that are associated with the ubiquitin system. USP9X is one of these targets, and has the potential to be a drug or biomarker.

The ubiquitin system is a complex protein degradation pathway that is involved in the regulation of protein stability and stability-dependent processes. The system consists of a series of proteins that act in a coordinated manner to remove damaged or unnecessary proteins from cells. Ubiquitin is one of the proteins that is involved in this process. It is a large protein that contains a number of conserved domains, including a N-terminal domain that is involved in protein-protein interactions and a C-terminal domain that is involved in protein-DNA interactions.

USP9X is a protein that is expressed in nearly all cell types, including neurons, muscle cells, and blood cells. It is a member of the ubiquitin system, and is involved in the regulation of protein stability and stability-dependent processes.

In recent years, researchers have identified numerous potential drug targets that are associated with the ubiquitin system. USP9X is one of these targets, and has the potential to be a drug or biomarker.

One of the key features of USP9X is its role in the regulation of DNA replication. DNA replication is a critical process that is essential for the survival of all living organisms. It is a process that requires the participation of a wide range of proteins, including enzymes that are involved in the regulation of DNA replication itself, as well as proteins that are involved in the stability of the DNA replication complex. USP9X is involved in the regulation of DNA replication, and is thought to play a key role in this process.

In addition to its role in DNA replication, USP9X is also involved in the regulation of protein stability and stability-dependent processes. As mentioned earlier, it is a member of the ubiquitin system, and is involved in the regulation of protein stability and stability- dependent processes. This suggests that USP9X may be involved in the regulation of protein stability, which could be a potential drug target.

Another potential mechanism by which USP9X may be involved in the regulation of protein stability is its role in the regulation of protein-protein interactions. Protein-protein interactions are important for the regulation of cellular processes, including cell signaling and division. USP9X is involved in the regulation of protein-protein interactions, and is thought to play a key role in this process.

In conclusion, USP9X is a protein that is expressed in nearly all cell types, and is involved in the regulation of protein stability and stability-dependent processes. It is a member of the ubiquitin system, and has the potential to be a drug target or biomarker. Further research is needed to fully understand the role of USP9X in the regulation of protein stability and stability-dependent processes.

Protein Name: Ubiquitin Specific Peptidase 9 X-linked

Functions: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:19135894, PubMed:25944111, PubMed:18254724, PubMed:22371489, PubMed:29626158). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:19135894, PubMed:25944111, PubMed:22371489, PubMed:18254724, PubMed:29626158). Specifically hydrolyzes 'Lys-63'-, 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains (PubMed:25944111, PubMed:18254724, PubMed:33378666). Essential component of TGF-beta/BMP signaling cascade (PubMed:19135894). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (PubMed:19135894). Deubiquitinates alkylation repair enzyme ALKBH3 (PubMed:25944111). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (PubMed:16322459). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:22371489). Deubiquitinates PEG10 (By similarity)

The "USP9X Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP9X comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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