USP5: A Potential Drug Target and Biomarker (G8078)

Target Name: USP5

NCBI ID: G8078

USP5

USP5: A Potential Drug Target and Biomarker

USP5, also known as Isopeptidase T, is a protein that is expressed in various tissues throughout the body. It is a member of the serine proteases family 5, which includes enzymes that belong to subfamilies G, H, and J. Isopeptidase T is characterized by its unique mechanism of action, which involves the cleavage of a specific peptide bond between the amino acids Asp and Asn residues on the substrate protein.

The importance of USP5 as a drug target or biomarker is its potential role in the treatment of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its unique mechanism of action, as well as its expression in a wide range of tissues, make it an attractive target for researchers and clinicians.

One of the key advantages of USP5 as a drug target is its ability to interact with a variety of different drugs. This is because its active site is loop-shaped, which allows it to bind to a wide range of different molecules. This means that USP5 can be used to treat a variety of different conditions, including but not limited to cancer, neurodegenerative disorders, and autoimmune diseases.

In addition to its potential as a drug target, USP5 also has potential as a biomarker. Its expression is highly upregulated in various tissues, including the brain, which makes it an attractive tool for the study of neurodegenerative disorders. Additionally, its expression is also highly upregulated in cancer cells, which makes it an attractive tool for the study of cancer.

Isopeptidase T has also been shown to have a variety of different functions in various tissues. For example, it has been shown to be involved in the regulation of inflammation, cell signaling, and neurotransmission. Additionally, it has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

Despite the potential benefits of USP5 as a drug target or biomarker, much research is still needed to fully understand its role in these processes. Additionally, the lack of specific inhibitors for USP5 makes it difficult to study its effects in a controlled manner.

In conclusion, USP5 is a protein that is expressed in various tissues throughout the body and has the potential to be a drug target or biomarker. Its unique mechanism of action, as well as its expression in a wide range of tissues, make it an attractive target for researchers and clinicians. Further research is needed to fully understand its role in various processes and to develop effective inhibitors.

Protein Name: Ubiquitin Specific Peptidase 5

Functions: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition

The "USP5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about USP5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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