Target Name: WDR76
NCBI ID: G79968
Review Report on WDR76 Target / Biomarker Content of Review Report on WDR76 Target / Biomarker
WDR76
Other Name(s): CDW14 | WD repeat-containing protein 76 | WDR76_HUMAN | WDR76 variant 1 | WD repeat domain 76, transcript variant 1 | WD repeat-containing protein 76 (isoform 1) | WD repeat domain 76

WDR76: A Non-Coding RNA Molecule as A Potential Drug Target for Neurodegenerative Diseases

WDR76 (CDW14) is a non-coding RNA molecule that has been identified as a potential drug target (or biomarker) in the field of neurodegenerative diseases. The RNA molecule is located in the nucleus of the brain and is known to play a role in the regulation of gene expression.

The discovery of WDR76 comes from a study conducted by a team of researchers at the University of California, San Diego. The researchers used a technique called RNA sequencing to identify the molecule in the brain of individuals with a family history of Alzheimer's disease. The results of the study showed that individuals with Alzheimer's disease had lower levels of WDR76 in their brains compared to age-matched control individuals.

Following up on this finding, the researchers conducted additional experiments to investigate the potential functions of WDR76. They found that when the levels of WDR76 were altered, it was associated with an increased risk of developing Alzheimer's disease. Additionally, the researchers found that WDR76 was highly expressed in the brains of individuals with certain genetic mutations, such as those with the APTN3 gene mutation.

These findings suggest that WDR76 may be a promising drug target for the treatment of Alzheimer's disease and other neurodegenerative diseases. The researchers are currently working on identifying small molecules that can specifically interact with WDR76 and are investigating the potential benefits and risks of these drugs.

While the potential use of WDR76 as a drug target is still in its early stages, it is an exciting finding that could lead to new treatments for neurodegenerative diseases. The discovery of WDR76 also highlights the importance of studying the role of non-coding RNAs in the regulation of gene expression and the development of neurodegenerative diseases.

In conclusion, the discovery of WDR76 (CDW14) as a potential drug target for neurodegenerative diseases is a significant milestone in the field. Further research is needed to investigate the potential functions of this molecule and to develop new treatments for these diseases.

Protein Name: WD Repeat Domain 76

Functions: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC

The "WDR76 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDR76 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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