KRTAP9-4: A Potential Drug Target for Various Diseases (G85280)

Target Name: KRTAP9-4

NCBI ID: G85280

KRTAP9-4

KRTAP9-4: A Potential Drug Target for Various Diseases

KRTAP9-4 (Ultrahigh sulfur keratin-associated protein 9.4) is a protein that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function make it an attractive target for researchers to study and develop new treatments.

Structure and Function

KRTAP9-4 is a 21-kDa protein that is expressed in a variety of tissues, including skin, hair, nails, and connective tissue. It is composed of a single polypeptide chain that contains 95% alpha-helices and 5% beta-helices. The protein has a unique 115 amino acid long terminal repeat, which is composed of 4 identical sequences followed by a variable amino acid. This repeat is found in the majority of tissues and is involved in protein stability and cell adhesion.

KRTAP9-4 functions as a negative regulator of the TGF-β pathway, which is a well-known signaling pathway that is involved in cell growth, differentiation, and survival. The TGF-β pathway is a critical regulator of cell proliferation and has been implicated in many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

KRTAP9-4 functions as a negative regulator of the TGF-β pathway by inhibiting the activity of the transcription factor, SMAD1. SMAD1 is a key regulator of the TGF-β pathway and is involved in the development and maintenance of tissues. By inhibiting the activity of SMAD1, KRTAP9-4 prevents the TGF-β pathway from activating and promoting the growth and development of cancer cells.

KRTAP9-4 has also been shown to play a role in the regulation of cell adhesion. The TGF-β pathway is involved in the regulation of cell-cell adhesion, and KRTAP9-4 has been shown to be involved in this process. This is evident from the fact that KRTAP9-4 is co-expressed with the adhesion molecule, E-cadherin, in many tissues.

KRTAP9-4 has also been shown to be involved in the regulation of the Wnt pathway, which is a critical regulator of cell growth and development. The Wnt pathway is involved in the development and maintenance of tissues and is implicated in many diseases, including cancer.

KRTAP9-4 functions as a negative regulator of the Wnt pathway by inhibiting the activity of the transcription factor, Wnt1. Wnt1 is a key regulator of the Wnt pathway and is involved in the development and maintenance of tissues. By inhibiting the activity of Wnt1, KRTAP9-4 prevents the Wnt pathway from activating and promoting the growth and development of cancer cells.

KRTAP9-4 has also been shown to play a role in the regulation of the Notch pathway, which is a critical regulator of cell growth and development. The Notch pathway is involved in the development and maintenance of tissues and is implicated in many diseases, including cancer.

KRTAP9-4 functions as a negative regulator of the Notch pathway by inhibiting the activity of the transcription factor, Notch1. Notch1 is a key regulator of the Notch pathway and is involved in the development and maintenance of tissues. By inhibiting the activity of Notch1, KRTAP9-4 prevents the Notch pathway from activating and promoting the growth and development of cancer cells.

KRTAP9-4 has also been shown to play a role in the regulation of the NF-kappa-B pathway, which is a critical regulator of inflammation and immune responses. The NF-kappa-B pathway is involved in the development and maintenance of tissues and is implicated in many diseases, including cancer and neurodegenerative diseases.

KRTAP9-4 functions as a negative regulator of the NF-kappa-B pathway by inhibiting the activity of the transcription factor,

Protein Name: Keratin Associated Protein 9-4

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP9-4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP9-4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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