CFAP53: A Protein Involved in Cilia and Flagella Regulation and Potential Drug Target

Target Name: CFAP53

NCBI ID: G220136

CFAP53

CFAP53: A Protein Involved in Cilia and Flagella Regulation and Potential Drug Target

CFAP53 (Cilia and Flagella Associated Protein 53) is a protein that is expressed in the cilia and flagella, which are the two types of flagella found in cells. Cilia and flagella are small organelles that are responsible for the movement of cells, and they are essential for the proper functioning of many cells. CFAP53 is a protein that is known to be involved in the regulation of cilia and flagella, and it is possible that it could be a drug target or biomarker.

CFAP53 is a 125-amino acid protein that is expressed in the cilia and flagella. It is characterized by a calculated molecular mass of 19.9 kDa and a predicted localization in the cytoplasm. CFAP53 is composed of two distinct domains: a N-terminal domain that contains a protein-coding region, and a C-terminal domain that is responsible for its stability and interaction with other proteins.

The N-terminal domain of CFAP53 is a 63 amino acid region that is responsible for the protein's localization in the cytoplasm. It includes a putative transmembrane region (TTR) that is involved in the formation of channels in the cytoplasm and the regulation of the movement of cells. The TTR is also home to several potential interactions with other proteins, including the cytoskeleton and the endoplasmic reticulum.

The C-terminal domain of CFAP53 is a 62 amino acid region that is responsible for the protein's stability and interaction with other proteins. It includes several potential interaction sites, including a leucine-rich repeat (LRR) domain that is known for its role in protein-protein interactions and a charged region that is involved in electrostatic interactions. The C-terminal domain also includes a 20 amino acid tail that is involved in the formation of a dimeric complex with the protein Fyn.

CFAP53 is involved in the regulation of cilia and flagella, which are organelles that are responsible for the movement of cells. Cilia are small, hair-like structures that are composed of a single layer of cilium protein, which is responsible for the production of mucus to protect the cell from external substances. Flagella are long, thread-like structures that are composed of a protein called DNS (Dihydroxy-N-acetyl-D-methoxyamine). DNS is responsible for generating the force that propels the flagella through the cytoplasm.

CFAP53 is thought to be involved in the regulation of cilia and flagella by controlling the structure and function of these organelles. For example, studies have shown that CFAP53 can interact with the cytoskeleton and the DNS, and that it is involved in the regulation of the movement of cells. It is also possible that CFAP53 is involved in the regulation of the production and degradation of cilia and flagella, as well as the interactions between these organelles.

CFAP53 is also a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and respiratory diseases. For example, studies have shown that CFAP53 is overexpressed in many types of cancer, and that it is involved in the regulation of cell growth and survival. It is also involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and has been shown to be involved in the development and progression of these conditions.

CFAP53 is also a potential drug target, as it is thought to be involved in the regulation of many cellular processes and is involved in the regulation of cilia and flagella. Drugs that target CFAP53

Protein Name: Cilia And Flagella Associated Protein 53

Functions: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis (PubMed:26531781)

The "CFAP53 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CFAP53 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets