CFAP45: Key Complement System Protein with Potential Drug Targets

Target Name: CFAP45

NCBI ID: G25790

CFAP45

CFAP45: Key Complement System Protein with Potential Drug Targets

CFAP45 (Complement Factor AP45) is a protein that is expressed in various tissues throughout the body, including the liver, spleen, and pancreas. It is a key component of the complement system, which is a group of proteins that work together to help the immune system fight off infections.

CFAP45 is a 21-kDa protein that consists of two heavy chains and two light chains. It is made up of 115 amino acids and has a calculated pI of around 6.5. CFAP45 is mainly localized to the endoplasmic reticulum (ER), where it is involved in the formation of the plasma membrane (PM) and various cell surface structures.

One of the unique features of CFAP45 is its ability to interact with the protein CRMP1 (Caspase-3-like molecule 1). CRMP1 is also a key component of the complement system and is expressed in various tissues throughout the body. The interaction between CFAP45 and CRMP1 has been shown to play a role in the regulation of inflammation and immune responses.

Another interesting property of CFAP45 is its ability to interact with the protein FERMT3 (F-actinin-associated protein 3). FERMT3 is also a key component of the complement system and is involved in the regulation of cell-cell adhesion. The interaction between CFAP45 and FERMT3 has been shown to play a role in the regulation of cellular processes such as cell migration and the formation of tissues such as the placenta and brain.

CFAP45 has also been shown to interact with the protein PDGF-BB (Platelet-derived growth factor-BB). PDGF-BB is a potent growth factor that is involved in the regulation of cellular processes such as cell growth, differentiation, and survival. The interaction between CFAP45 and PDGF-BB has been shown to play a role in the regulation of cellular processes such as wound healing and tissue repair.

CFAP45 has also been shown to interact with the protein NF-kappa-B (nuclear factor kappa B). NF-kappa-B is a transcription factor that is involved in the regulation of various cellular processes, including inflammation and immune responses. The interaction between CFAP45 and NF-kappa-B has been shown to play a role in the regulation of cellular processes such as inflammation and immune responses.

CFAP45 has been shown to have a number of potential drug targets, including the inhibition of Caspase-3-like molecule 1 (CRMP1) and the inhibition of F-actinin-associated protein 3 (FERMT3). These drugs have been shown to have a number of potential therapeutic benefits, including the treatment of various diseases such as cancer, neurodegenerative diseases, and autoimmune diseases.

In addition to its potential drug targets, CFAP45 also has a number of potential biomarkers. For example, the level of CFAP45 has been shown to be elevated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Additionally, the level of CFAP45 has been shown to be regulated by various factors, including the amount of CRMP1 and FERMT3 present in the cell.

Overall, CFAP45 is a protein that has a number of unique properties and functions in the body. Its ability to interact with other proteins in the complement system, as well as its potential drug targets and biomarkers, make it an interesting target for research and development. Further studies are needed to fully understand the role of CFAP45 in the regulation of cellular processes and its potential as a therapeutic agent.

Protein Name: Cilia And Flagella Associated Protein 45

Functions: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis. May function as a donor of AMP to AK8 and hence promote ADP production (PubMed:33139725)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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