Cilia- and flagella-associated protein 44 (CFAP44): A Potential Drug Target and Biomarker

Target Name: CFAP44

NCBI ID: G55779

CFAP44

Cilia- and flagella-associated protein 44 (CFAP44): A Potential Drug Target and Biomarker

Cilia and flagella are essential organelles that play a critical role in the function of epithelial cells. They are composed of a unique protein complex that includes multiple proteins, including Cilia- and flagella-associated protein 44 (CFAP44). CFAP44 is a 12.9 kDa protein that is expressed in high levels in various epithelial tissues, including the skin, gut, and respiratory tract. Its functions are still well understood, but research has identified several potential roles for CFAP44 in cell signaling and tissue development.

CFAP44: Structure and Functions

The structure of CFAP44 is highly conserved among various species, including humans. It consists of a unique protein domain that includes a long amino acid sequence responsible for its unique structure and function. The protein has a characteristic Rossmann-fold that is involved in protein-protein interactions and is essential for its stability. Additionally, CFAP44 has a distinct N-terminus that is involved in the formation of a complex with the nucleotide GDP.

CFAP44 functions as a scaffold protein that plays a critical role in the formation of cilium and flagella. Cilia and flagella are essential organelles that help maintain the integrity of epithelial barriers and play a crucial role in cell signaling. The formation of cilium and flagella is a complex process that involves multiple proteins, including CFAP44.

CFAP44 has been shown to play a critical role in the regulation of cilium formation and the maintenance of flagellum stability. Studies have shown that CFAP44 plays a critical role in the organization of the cilium and flagella filaments. CFAP44 has been shown to interact with the protein F-actinin, which is involved in the regulation of cilium formation. Additionally, CFAP44 has been shown to interact with the protein Myosin, which is involved in the regulation of flagellum stability.

CFAP44 has also been shown to play a critical role in the regulation of cell signaling. Studies have shown that CFAP44 is involved in the regulation of TGF-β signaling, which is a critical pathway involved in cell signaling and growth. Additionally, CFAP44 has been shown to be involved in the regulation of Wnt signaling, which is a critical pathway involved in cell signaling and development.

CFAP44 as a Potential Drug Target

The identification of CFAP44 as a potential drug target has significant implications for the development of new therapeutic approaches for various diseases. CFAP44 has been shown to play a critical role in the regulation of cilium formation and flagellum stability, which are critical processes involved in the development and maintenance of epithelial tissues.

Studies have shown that various drugs that have been developed to treat various diseases, including cancer, have the potential to modulate CFAP44 levels or its functions. For example, studies have shown that inhibitors of the protein PDGF-BB, which is involved in cell signaling, have the potential to inhibit the growth of cancer cells. Similarly, studies have shown that inhibitors of the protein NF-kappa-B, which is involved in inflammation, have the potential to treat various inflammatory diseases.

CFAP44 has also been shown to play a critical role in the regulation of cell signaling and has the potential to be a drug target for various diseases. For example, studies have shown that inhibitors of the protein PDGF-BB, which is involved in cell signaling, have the potential to treat various diseases, including cancer. Similarly, studies have shown that inhibitors of

Protein Name: Cilia And Flagella Associated Protein 44

Functions: Flagellar protein involved in sperm flagellum axoneme organization and function

The "CFAP44 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CFAP44 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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