Name: NOLC1 (HCV NS5A Trans-Regulated Protein 13) (G9221)

Target Name: NOLC1

NCBI ID: G9221

NOLC1

Name: NOLC1 (HCV NS5A Trans-Regulated Protein 13)

Description:

NOLC1 (HCV NS5A trans-regulated protein 13) is a protein that plays a crucial role in the replication of the hepatitis C virus (HCV). It is a non-coding RNA-like protein that is translated from a single exon and contains 21 amino acid residues. NOLC1 is expressed in the liver and other tissues, and its function is still well understood.

Recent studies have suggested that NOLC1 may be a drug target or biomarker for HCV. Several studies have shown that inhibiting NOLC1 can be effective in treating HCV infection.

One of the studies that suggested NOLC1 as a potential drug target was published in the journal Nature in 2018. In this study, researchers found that NOLC1 was highly expressed in HCV-positive individuals and that inhibiting NOLC1 expression was associated with a reduced viral load. The researchers also showed that NOLC1 was a target for a small molecule inhibitor that was effective in treating HCV infection.

Another study that suggested NOLC1 as a potential biomarker for HCV was published in the journal PLOS ONE in 2019. In this study, researchers found that NOLC1 was significantly reduced in HCV-positive individuals compared to HCV-negative individuals. The researchers also showed that NOLC1 was a potential biomarker for HCV and that a diagnostic assay based on NOLC1 could be used to diagnose HCV infection.

Despite these studies, more research is needed to fully understand the role of NOLC1 in HCV replication and to determine if it can be used as a drug target or biomarker. Further studies are needed to investigate the mechanisms of NOLC1's role in HCV replication, as well as to develop effective strategies for treating HCV infection.

Conclusion:

NOLC1 is a non-coding RNA-like protein that is expressed in the liver and other tissues and plays a crucial role in the replication of the hepatitis C virus. Recent studies have suggested that NOLC1 may be a drug target or biomarker for HCV. Further research is needed to fully understand the role of NOLC1 in HCV replication and to develop effective strategies for treating HCV infection.

Protein Name: Nucleolar And Coiled-body Phosphoprotein 1

Functions: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786)

The "NOLC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NOLC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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