GAB2: Potential Drug Targets and Biomarker for Neurological Disorders

Target Name: GAB2

NCBI ID: G9846

GAB2

GAB2: Potential Drug Targets and Biomarker for Neurological Disorders

GAB2 (growth factor receptor bound protein 2-associated protein 2) is a protein that is expressed in various tissues throughout the body, including the brain, nervous system, and endocrine system. It is a member of the GABA-Bergmann gene family, which is known for the production of gamma-aminobutyric acid (GABA) receptors, which are involved in a variety of physiological processes, including neurotransmission and signaling.

GAB2 has been shown to play a role in the regulation of a wide range of physiological processes, including neuronal excitability, synaptic plasticity, and stress response. It is involved in the development and maintenance of the functional integrity of neurons, and is thus a potential drug target for a variety of neurological and psychiatric disorders.

One of the key functions of GAB2 is its role in modulating the activity of GABA receptors, which are known for their role in the regulation of neurotransmitter release and synaptic plasticity. GAB2 has been shown to interact with GABA receptors and modulate their activity, which can have a profound impact on neural function.

In addition to its role in modulating GABA receptor activity, GAB2 is also involved in the regulation of a variety of other signaling pathways that are important for brain development and function. For example, GAB2 has been shown to be involved in the regulation of cell migration , and is thus a potential target for the development of new therapies for a variety of neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease.

GAB2 is also of interest as a potential biomarker for a variety of neurological disorders. The loss of GAB2 has been observed in a variety of neurodegenerative diseases, including Alzheimer's disease, and its levels have been found to be elevated in the brains of individuals with these disorders. Therefore, GAB2 may be a useful biomarker for the diagnosis and progression of these disorders.

Another potential application of GAB2 as a drug target is its role in the regulation of pain. GAB2 has been shown to play a role in the regulation of pain signaling, and is thus a potential target for the development of new pain therapies.

In conclusion, GAB2 is a protein that has important roles in the regulation of a wide range of physiological processes, including neuronal excitability, synaptic plasticity, and stress response. Its involvement in the regulation of GABA receptor activity and the regulation of other signaling pathways makes it a potential drug target for a variety of neurological and psychiatric disorders. As a potential biomarker for a variety of neurodegenerative diseases, GAB2 may also be a useful target for the development of new therapies for these disorders. Further research is needed to fully understand the role of GAB2 in these processes and to develop effective treatments.

Protein Name: GRB2 Associated Binding Protein 2

Functions: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis

The "GAB2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GAB2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets