Understanding Tankyrase: Potential Drug Target for Cancer and Inflammation

Target Name: Tankyrase

NCBI ID: P6950

Tankyrase

Other Name(s): TRF1-Interacting Ankyrin Related ADP-ribose Polymerase

Understanding Tankyrase: Potential Drug Target for Cancer and Inflammation

Tankyrase (TRF1-Interacting Ankyrin Related ADP-ribose Polymerase) is a protein that plays a critical role in the biosynthesis of adenosine, a molecule that has several important functions in the body, including modulating inflammation, improving immune responses, and regulating blood pressure. Tankyrase is a key enzyme in the adenosine biosynthesis pathway, and its function is crucial for the proper functioning of this important molecule.

TRF1, also known as Tankyrase, is a protein that is characterized by the presence of a distinct N-terminus and a C-terminus that is involved in the interaction with TRF2, another protein that is known to modulate the activity of Tankyrase. The N-terminus of TRF1 contains a putative RNA-binding domain, which is thought to play a role in the regulation of gene expression.

In addition to its role in adenosine biosynthesis, Tankyrase has also been shown to have a number of potential drug-like properties. For example, Tankyrase has been shown to be a potential drug target in cancer, as it has been shown to be involved in the regulation of cell proliferation and survival. Additionally, Tankyrase has also been shown to be involved in the regulation of inflammation, as it has been shown to play a role in the production of pro-inflammatory cytokines.

Despite its potential as a drug target, Tankyrase is not yet a widely recognized drug candidate. This is likely due to the fact that its function and mechanism of action are not yet fully understood, as well as the difficulty in obtaining high-quality purified protein samples.

In conclusion, Tankyrase is a protein that plays a critical role in the biosynthesis of adenosine, a molecule that has several important functions in the body. Its function is crucial for the proper functioning of this molecule, and as a result, it has a high potential as a drug target. Further research is needed to fully understand the function and mechanism of Tankyrase, and to develop it as a drug candidate for the treatment of various diseases.

Protein Name: Tankyrase (nonspecified Subtype)

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•   general information;
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•   expression level;
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