Target Name: RNF13
NCBI ID: G11342
Review Report on RNF13 Target / Biomarker Content of Review Report on RNF13 Target / Biomarker
RNF13
Other Name(s): RING zinc finger protein | FLJ93817 | Ring finger protein 13, transcript variant 1 | E3 ubiquitin-protein ligase RNF13 | ring finger protein 13 | RNF13 variant 4 | RNF13_HUMAN | MGC13689 | RNF13 variant 1 | DEE73 | EIEE73 | RING finger protein 13 | E3 ubiquitin-protein ligase RNF13 (isoform 1) | RZF | Ring finger protein 13, transcript variant 4 | RING-type E3 ubiquitin transferase RNF13

RING ZNPs: RNA-Binding Proteins with Potential as Drug Targets Or Biomarkers

RNA-binding proteins (RBP) play a crucial role in gene regulation and have been implicated in various diseases, including cancer. One class of RNA-binding proteins is the zinc finger proteins (ZNPs), which contain a specific domain composed of a nucleotide-binding oligomerization (NBO) domain and a variable region. One of the subfamilies of ZNPs is the Ring-shaped ZNPs (RING ZNPs), which are characterized by a central ring-shaped domain and a C-terminal domain that can interact with RNA. RING ZNPs have been implicated in various cellular processes, including cell growth, differentiation, and stress response.

One of the key features of RING ZNPs is their ability to interact with specific RNAs. This interaction is mediated by the NBO domain, which consists of a parallel beta-sheet structure that contains a conserved core region and a variable loop region. The NBO domain is responsible for the interaction with RNA through a variety of mechanisms, including the formation of RNA-protein complexes and the regulation of RNA stability.

RING ZNPs have been shown to play important roles in various cellular processes, including cell growth, differentiation, and stress response. For example, RING ZNPs have been shown to be involved in the regulation of cell growth and have been implicated in the development of various types of cancer. In addition, RING ZNPs have also been shown to play important roles in the regulation of cell differentiation, including the regulation of stem cell maintenance and the development of tissues such as brain and heart.

In addition to their roles in cellular processes, RING ZNPs have also been shown to be involved in the regulation of gene expression. For example, RING ZNPs have been shown to interact with specific RNA transcripts and regulate their stability and translation efficiency. This regulation of gene expression is important for the development and maintenance of various cellular processes and is a potential drug target for RING ZNPs.

Given their involvement in various cellular processes and their ability to interact with specific RNAs, RING ZNPs have potential as drug targets or biomarkers. For example, RING ZNPs that have been shown to interact with specific RNAs could be targeted with drugs that are designed to inhibit their interaction with those RNAs. This approach could be useful for the treatment of various diseases, including cancer. In addition, the regulation of RING ZNPs has been shown to be involved in various cellular processes, including cell growth, differentiation, and stress response. This regulation could be potential target for drugs that are designed to modulate these processes.

In conclusion, RING ZNPs are a class of RNA-binding proteins that have been shown to play important roles in various cellular processes. Their ability to interact with specific RNAs and their involvement in the regulation of gene expression make them potential drug targets or biomarkers. Further research is needed to fully understand the role of RING ZNPs in cellular processes and their potential as drug targets or biomarkers.

Protein Name: Ring Finger Protein 13

Functions: E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371). Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). Also involved in protein trafficking and localization (PubMed:24387786)

The "RNF13 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF13 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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