TMEM18: A Transmembrane Protein Target for Drug Development and Disease Treatment

Target Name: TMEM18

NCBI ID: G129787

TMEM18

TMEM18: A Transmembrane Protein Target for Drug Development and Disease Treatment

TMEM18, or Transmembrane Protein 18, is a gene that encodes a protein involved in various physiological processes in the body. The protein has been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. In this article, we will explore the biology of TMEM18 and its potential as a drug target.

Background

TMEM18 is a member of the transmembrane protein (TMEM) family, which are a diverse group of proteins that span the cell membrane and interact with various intracellular and extracellular signaling molecules. TMEM18 is characterized by a long extracellular domain, a transmembrane segment, and a short cytoplasmic tail.

Expression and localization

TMEM18 is widely expressed in various tissues and organs, including brain, heart, liver, and pancreas. Its expression is highly dependent on the tissue and developmental stage, with high levels of expression in the brain and low levels in the liver during the adult stage. TMEM18 is also known to be expressed in various types of cancer, including breast, ovarian, and colorectal cancer.

Function and localization

TMEM18 is involved in various physiological processes, including cell signaling, intracellular signaling, and tissue structure. Its primary function is to regulate the diffusion of ion channels in the membrane. TMEM18 plays a critical role in the regulation of sodium (Na+) and calcium (Ca2+) channels, which are involved in various cellular processes, including muscle contractions, nerve signaling, and blood clotting.

TMEM18 has been shown to localize to the endoplasmic reticulum (ER) and to be involved in the regulation of intracellular signaling pathways. Its localization to the ER has been confirmed by various techniques, including immunofluorescence and biochemical assays. TMEM18 has also been shown to play a role in regulating the level of protein synthesis in the cell, which is critical for the development and progression of cancer.

Drug targeting

TMEM18 has emerged as a promising drug target due to its involvement in various cellular processes that are involved in cancer, neurodegenerative disorders, and autoimmune diseases. Several studies have shown that inhibition of TMEM18 can lead to the inhibition of various cellular processes that are involved in the development and progression of these diseases.

For example, TMEM18 has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. The inhibition of TMEM18 has been shown to lead to the inhibition of angiogenesis and the suppression of blood vessel formation. This has potential implications for the treatment of various cardiovascular diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

In addition, TMEM18 has been shown to be involved in the regulation of cell signaling pathways that are involved in cancer progression. The inhibition of TMEM18 has been shown to lead to the inhibition of various cellular processes that are involved in the development and progression of cancer. This has potential implications for the treatment of various types of cancer.

TMEM18 has also been shown to be involved in the regulation of protein synthesis in the cell, which is critical for the development and progression of cancer. The inhibition of TMEM18 has been shown to lead to the inhibition of protein synthesis and the suppression of cellular processes that are involved in cancer progression. This has potential implications for the treatment of cancer.

Biochemical and cellular assays

Several studies have shown that TMEM18 is involved in the regulation of various cellular processes that are involved in cancer, neurodegenerative disorders, and autoimmune diseases. These studies have involved the use of various techniques, including biochemical assays, cell-based assays, and animal models of disease.

One of the most promising assays for the

Protein Name: Transmembrane Protein 18

Functions: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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