ZDHHC8BP: A Potential Drug Target and Biomarker (G150244)

Target Name: ZDHHC8BP

NCBI ID: G150244

ZDHHC8BP

Other Name(s): ZDHHC8P | ZDHHC8P1 | ZDHHC8B, pseudogene

ZDHHC8BP: A Potential Drug Target and Biomarker

ZDHHC8BP, also known as ZDHHC8P, is a protein that is expressed in various tissues and cells throughout the body. Its unique structure and expression pattern have caught the attention of researchers due to its potential role in drug development and disease diagnosis. In this article, we will explore the ZDHHC8BP protein, its expression pattern, potential drug targets, and implications for disease.

Structure and Expression

The ZDHHC8BP protein is a member of the Zinc Finger N-terminal domain (ZFN) superfamily, which is characterized by a specific N-terminal Zinc Finger and a variable C-terminal region. ZDHHC8BP has a unique ZFN-like structure, with a short N-terminal Zinc Finger and a long C-terminal region that contains a unique set of amino acids, known as the 8-beta subunit.

ZDHHC8BP is expressed in various tissues and cells throughout the body, including the brain, pancreas, heart, and gastrointestinal tract. Its expression pattern varies depending on the specific cell type and the developmental stage of the organism. For example, high levels of ZDHHC8BP expression have been observed in pancreatic ductal adenocarcinoma, a type of pancreatic cancer, as well as in the hearts of mice.

Potential Drug Targets

The unique structure and expression pattern of ZDHHC8BP make it an attractive drug target. Its N-terminal Zinc Finger domain has been shown to play a role in protein-protein interactions and is involved in the regulation of various cellular processes. Therefore, potential drug targets for ZDHHC8BP may include modulating its expression, activity, or interactions with other proteins.

One potential drug target for ZDHHC8BP is the protein p120GAP, which is a known regulator of the N-terminal Zinc Finger domain. p120GAP has been shown to interact with ZDHHC8BP and modulate its activity. Therefore, inhibiting p120GAP activity may be a potential strategy for targeting ZDHHC8BP.

Another potential drug target for ZDHHC8BP is the protein FAK, which is involved in cell adhesion, migration, and invasion. ZDHHC8BP has been shown to interact with FAK and contribute to its activity. Therefore, targeting FAK activity may be a potential strategy for treating diseases that are characterized by the excessive activity of FAK.

Biomarker Potential

The unique expression pattern of ZDHHC8BP makes it an attractive biomarker for various diseases. For example, high levels of ZDHHC8BP expression have been observed in pancreatic ductal adenocarcinoma, a type of pancreatic cancer. Therefore, ZDHHC8BP may be a potential biomarker for pancreatic cancer.

In addition, ZDHHC8BP has also been shown to be involved in the regulation of various cellular processes, including cell adhesion, migration, and invasion. Therefore, its expression level may be an indicator of the severity of certain diseases, such as cancer.

Conclusion

In conclusion, ZDHHC8BP is a unique protein with a ZFN-like structure and expressed in various tissues and cells throughout the body. Its potential role as a drug target and biomarker makes it an attractive target for research in the field of pharmacology. Further studies are needed to fully understand the role of ZDHHC8BP in disease progression and the development of new therapeutic strategies.

Protein Name: ZDHHC8B, Pseudogene

The "ZDHHC8BP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZDHHC8BP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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