Carbonic Anhydrase (nonspecified subtype) Related Diseases

Carbonic Anhydrase (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Hypokalemic Periodic Paralysis
Hypokalemic Periodic Paralysis, Type 1, also known as hypokalemic periodic paralysis, is related to hypokalemic periodic paralysis, type 2 and thyrotoxic periodic paralysis, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Hypokalemic Periodic Paralysis, Type 1 is CACNA1S (Calcium Voltage-Gated Channel Subunit Alpha1 S), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and CREB Pathway. The drugs Hops and Diclofenamide have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, thyroid and small intestine, and related phenotypes are periodic hypokalemic paresis and episodic hypokalemia

3) Metabolic Diseases
3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as hadh deficiency, is related to long-chain 3-hydroxyacyl-coa dehydrogenase deficiency and hyperinsulinemic hypoglycemia, familial, 4, and has symptoms including emaciation An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (Hydroxyacyl-CoA Dehydrogenase). The drugs Naloxone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related phenotypes are feeding difficulties in infancy and growth delay

4) Postpartum Depression
Postpartum Depression, also known as depression, postpartum, is related to major depressive disorder and mood disorder, and has symptoms including pelvic pain and mental and behavioral signs and symptoms. An important gene associated with Postpartum Depression is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are Signal Transduction and Myometrial relaxation and contraction pathways. The drugs Copper and Ethinylestradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and thyroid, and related phenotypes are nervous system and homeostasis/metabolism

5) Diabetes Type 2
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

6) Cysticercosis
Cysticercosis, also known as neurocysticercosis, is related to echinococcosis and schistosomiasis. An important gene associated with Cysticercosis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Praziquantel and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skin, and related phenotypes are cerebral calcification and functional motor deficit

7) Hypopituitarism
Hypopituitarism, also known as pituitary insufficiency, is related to combined pituitary hormone deficiencies, genetic forms and culler-jones syndrome. An important gene associated with Hypopituitarism is PROP1 (PROP Paired-Like Homeobox 1), and among its related pathways/superpathways are Signal Transduction and G-Beta Gamma Signaling. The drugs Epitestosterone and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and brain, and related phenotypes are no effect and no effect

8) Glioblastoma Multiforme
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology

9) Open-angle Glaucoma
Open-Angle Glaucoma, also known as glaucoma, open-angle, is related to glaucoma 1, open angle, a and exfoliation syndrome. An important gene associated with Open-Angle Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are Extracellular matrix organization and Burn wound healing. The drugs Tobramycin and Polymyxin B have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and endothelial, and related phenotypes are nervous system and homeostasis/metabolism

10) Myocarditis
Myocarditis, also known as myocardial inflammation, is related to autoimmune myocarditis and rheumatic myocarditis. An important gene associated with Myocarditis is BAG3 (BAG Cochaperone 3), and among its related pathways/superpathways are Innate Immune System and Cardiac conduction. The drugs Abatacept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and t cells, and related phenotypes are no effect and no effect

11) Binge Eating Disorder
Bulimia Nervosa, also known as bulimia, is related to abdominal obesity-metabolic syndrome 1 and polysubstance abuse, and has symptoms including salt craving, symptoms and decrease in appetite. An important gene associated with Bulimia Nervosa is BULN (Bulimia Nervosa, Susceptibility To), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Memantine and Sibutramine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, prefrontal cortex and skin, and related phenotypes are bulimia and nervous system

12) Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, also known as lymphangiomyomatosis, is related to tuberous sclerosis 1 and tuberous sclerosis. An important gene associated with Lymphangioleiomyomatosis is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Doxycycline and Antimalarials have been mentioned in the context of this disorder. Affiliated tissues include lung, smooth muscle and skin, and related phenotypes are dyspnea and cough

13) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

14) Malaria
Malaria, also known as malaria, susceptibility to, is related to plasmodium falciparum malaria and plasmodium vivax malaria, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Malaria is SLC4A1 (Solute Carrier Family 4 Member 1 (Diego Blood Group)), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Lumefantrine and Artemether have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and t cells, and related phenotypes are nausea and vomiting and fever

15) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

16) Gout
Gout, also known as gouty arthritis, is related to tubulointerstitial kidney disease, autosomal dominant, 1 and phosphoribosylpyrophosphate synthetase superactivity, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Gout is DARS2 (Aspartyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Drug ADME. The drugs Allopurinol and Febuxostat have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and skin, and related phenotypes are no effect and no effect

17) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

18) Cancer, Bladder
Bladder Cancer, also known as urinary bladder cancer, is related to bladder urothelial carcinoma and costello syndrome. An important gene associated with Bladder Cancer is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Tamsulosin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include urinary bladder, lymph node and prostate, and related phenotypes are transitional cell carcinoma of the bladder and bladder neoplasm

19) Epilepsy
Epilepsy, also known as epilepsy syndrome, is related to epilepsy, myoclonic juvenile and childhood absence epilepsy, and has symptoms including back pain, headache and pain. An important gene associated with Epilepsy is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Ethosuximide and Vigabatrin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and thalamus, and related phenotypes are nervous system and growth/size/body region

20) Leukoplakia
Leukoplakia, also known as leukoplakia of oral epithelium, is related to oral leukoplakia and lip and oral cavity cancer. An important gene associated with Leukoplakia is DKC1 (Dyskerin Pseudouridine Synthase 1), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Keratinization. The drugs Rosiglitazone and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include tongue, cervix and bone marrow, and related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).

21) Glioma
Glial Tumor, also known as glioma, is related to optic nerve glioma and brain stem glioma. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone marrow.

22) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

23) Acne
Acne, also known as acne vulgaris, is related to sapho syndrome and hidradenitis suppurativa, and has symptoms including exanthema and pruritus. An important gene associated with Acne is NCSTN (Nicastrin), and among its related pathways/superpathways are Innate Immune System and Prolactin Signaling. The drugs Calcipotriol and Adapalene have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and thyroid, and related phenotypes are no effect and no effect

24) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

25) Diabetic Neuropathy
Diabetic Neuropathy, also known as diabetic neuropathies, is related to microvascular complications of diabetes 3 and diabetic polyneuropathy, and has symptoms including neuralgia and sciatica. An important gene associated with Diabetic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and CREB Pathway. The drugs Histamine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and dorsal root ganglion, and related phenotypes are no effect and no effect

26) Tuberculosis
Mycobacterium Tuberculosis 1, also known as tuberculosis, is related to pulmonary tuberculosis and miliary tuberculosis, and has symptoms including coughing, fever and pruritus. An important gene associated with Mycobacterium Tuberculosis 1 is MTBS1 (Mycobacterium Tuberculosis, Susceptibility To Infection By, 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Calcium carbonate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include lungs, lymph nodes and pericardium, and related phenotypes are fatigue and fever

27) Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

28) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

29) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

30) Spinal Muscular Atrophy
Spinal Muscular Atrophy, also known as sma, is related to spinal muscular atrophy, distal, autosomal recessive, 1 and spinal muscular atrophy, x-linked 2, and has symptoms including back pain, headache and pain. An important gene associated with Spinal Muscular Atrophy is SMN1 (Survival Of Motor Neuron 1, Telomeric), and among its related pathways/superpathways is SARS-CoV-2 modulates host translation machinery. The drugs Acetaminophen and Risdiplam have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skeletal muscle and tongue, and related phenotypes are no effect and no effect

31) Intracerebral Hemorrhage
Hemorrhage, Intracerebral, also known as intracerebral hemorrhage, is related to cerebral amyloid angiopathy, app-related and porencephaly, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Hemorrhage, Intracerebral is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Signaling by Receptor Tyrosine Kinases and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Progesterone and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are growth/size/body region and nervous system

32) Cerebrovascular Disorders
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

33) Keratosis, Actinic
Actinic Keratosis, also known as solar keratosis, is related to keratosis and squamous cell carcinoma. An important gene associated with Actinic Keratosis is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Toll-Like receptor Signaling Pathways. The drugs Prilocaine and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and liver, and related phenotypes are endocrine/exocrine gland and neoplasm

34) Psoriasis
Psoriasis is related to psoriasis 7 and psoriasis 10, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis is MIR203A (MicroRNA 203a), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Metformin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

35) Amebiasis
Amebiasis, also known as amoebiasis, is related to dysentery and giardiasis. An important gene associated with Amebiasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sodium citrate and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and brain, and related phenotypes are homeostasis/metabolism and neoplasm

36) Glaucoma
Intraocular Pressure Quantitative Trait Locus, also known as glaucoma, is related to primary angle-closure glaucoma and open-angle glaucoma. An important gene associated with Intraocular Pressure Quantitative Trait Locus is ZEB1 (Zinc Finger E-Box Binding Homeobox 1), and among its related pathways/superpathways are Clear cell renal cell carcinoma pathways and BMP signaling in eyelid development. The drugs Topiramate and Bromfenac have been mentioned in the context of this disorder. Affiliated tissues include Eye, retina and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

37) Osteoarthritis
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

38) Osteoporosis
Bone Mineral Density Quantitative Trait Locus 8, also known as osteoporosis, is related to osteoporosis and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Bone Mineral Density Quantitative Trait Locus 8 is BMND8 (Bone Mineral Density Quantiative Trait Locus 8). The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord.

39) Hyperlipidemia
Familial Hyperlipidemia, also known as familial hyperlipoproteinemia, is related to hyperlipoproteinemia, type v and hyperlipoproteinemia, type i. An important gene associated with Familial Hyperlipidemia is APOB (Apolipoprotein B), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Evolocumab and Dapagliflozin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and endothelial, and related phenotypes are no effect and no effect

40) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

41) Hyperkalemic Periodic Paralysis
Hyperkalemic Periodic Paralysis, also known as gamstorp disease, is related to myotonia, potassium-aggravated and periodic paralysis, and has symptoms including stridor, muscular stiffness and myalgia. An important gene associated with Hyperkalemic Periodic Paralysis is SCN4A (Sodium Voltage-Gated Channel Alpha Subunit 4), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Cardiac conduction. The drugs Hops and Diclofenamide have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, heart and tongue, and related phenotypes are emg abnormality and reduced tendon reflexes

42) Macular Degeneration
Macular Degeneration, Age-Related, 1, also known as macular degeneration, is related to macular degeneration, age-related, 4 and retinoschisis 1, x-linked, juvenile, and has symptoms including vision loss, angina pectoris and tremor. An important gene associated with Macular Degeneration, Age-Related, 1 is HMCN1 (Hemicentin 1), and among its related pathways/superpathways is Complement cascade. The drugs Bevacizumab and Verteporfin have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are macular hemorrhage and macular degeneration

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