Interleukin 17 (nonspecified subtype) Related Diseases

Interleukin 17 (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Crohn's Disease
Crohn's Disease, also known as crohn disease, is related to inflammatory bowel disease and inflammatory bowel disease 1, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are no effect and no effect

3) Congestive Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

4) Metabolic Diseases
3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as hadh deficiency, is related to long-chain 3-hydroxyacyl-coa dehydrogenase deficiency and hyperinsulinemic hypoglycemia, familial, 4, and has symptoms including emaciation An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (Hydroxyacyl-CoA Dehydrogenase). The drugs Naloxone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related phenotypes are feeding difficulties in infancy and growth delay

5) Diabetes Type 1
Type 1 Diabetes Mellitus, also known as diabetes mellitus, insulin-dependent, is related to type 1 diabetes mellitus 12 and type 1 diabetes mellitus 5, and has symptoms including polyuria and polydipsia. An important gene associated with Type 1 Diabetes Mellitus is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are IL-9 Signaling Pathways and Immune response NFAT in immune response. The drugs Rituximab and Glipizide have been mentioned in the context of this disorder. Affiliated tissues include Bone and Pancreas, and related phenotypes are diabetes mellitus and polydipsia

6) Arthritis, Psoriatic
Psoriatic Arthritis, also known as psoriatic arthritis, susceptibility to, is related to spondyloarthropathy 1 and juvenile rheumatoid arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Psoriatic Arthritis is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Methotrexate and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

7) Hidradenitis Suppurativa
Hidradenitis Suppurativa, also known as acne inversa, is related to dowling-degos disease and inflammatory bowel disease 1, and has symptoms including painful nodules, exanthema and pruritus. An important gene associated with Hidradenitis Suppurativa is NCSTN (Nicastrin), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Triamcinolone and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lymph node, and related phenotypes are no effect and no effect

8) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

9) Pyoderma Gangrenosum
Pyoderma Gangrenosum, also known as phagedenic pyoderma, is related to pyogenic sterile arthritis, pyoderma gangrenosum, and acne and neutrophilic dermatosis, acute febrile. An important gene associated with Pyoderma Gangrenosum is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Integrin Pathway. The drugs Mitogens and Endothelial Growth Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and myeloid, and related phenotypes are fever and skin ulcer

10) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

11) Multiple Sclerosis, Primary Progressive
Primary Progressive Multiple Sclerosis, also known as multiple sclerosis, primary progressive, is related to relapsing-remitting multiple sclerosis and multiple sclerosis. An important gene associated with Primary Progressive Multiple Sclerosis is MOG (Myelin Oligodendrocyte Glycoprotein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dalfampridine and Potassium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are immune system and no phenotypic analysis

12) Multiple Sclerosis, Relapsing-remitting
Relapsing-Remitting Multiple Sclerosis, also known as relapsing-remitting ms, is related to secondary progressive multiple sclerosis and multiple sclerosis. An important gene associated with Relapsing-Remitting Multiple Sclerosis is TUG1 (Taurine Up-Regulated 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Alemtuzumab and Phylloquinone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related phenotypes are growth/size/body region and homeostasis/metabolism

13) Multiple Sclerosis, Secondary Progressive
Secondary Progressive Multiple Sclerosis, also known as multiple sclerosis, secondary progressive, is related to relapsing-remitting multiple sclerosis and multiple sclerosis. An important gene associated with Secondary Progressive Multiple Sclerosis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are superpathway of L-citrulline metabolism and Amino acid metabolism. The drugs Dalfampridine and Cladribine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and spinal cord, and related phenotypes are immune system and hematopoietic system

14) Endometriosis
Endometriosis, also known as endometriosis, site unspecified, is related to endometriosis of ovary and endometrial adenocarcinoma, and has symptoms including pelvic pain and pain and other symptoms associated with female genital organs. An important gene associated with Endometriosis is ENDO1 (Endometriosis, Susceptibility To, 1), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Dienogest and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and skin.

15) Kawasaki Disease
Kawasaki Disease, also known as mucocutaneous lymph node syndrome, is related to exanthem and conjunctivitis, and has symptoms including fever, congestion of ocular conjunctivae and reddening of lips. An important gene associated with Kawasaki Disease is THRIL (TNF And HNRNPL Related Immunoregulatory Long Non-Coding RNA), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Immunoglobulin G and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include body, lymph node and heart, and related phenotypes are proteinuria and cheilitis

16) Giant Cell Arteritis
Temporal Arteritis, also known as polymyalgia rheumatica, is related to myocarditis and arteritic anterior ischemic optic neuropathy, and has symptoms including back pain, exanthema and muscle cramp. An important gene associated with Temporal Arteritis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and eye, and related phenotypes are joint stiffness and fatigue

17) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

18) Lichen Planus
Lichen Planus, also known as lichen ruber planus, is related to stomatitis and pemphigoid, and has symptoms including pruritus An important gene associated with Lichen Planus is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Extracellular matrix organization and COPI-independent Golgi-to-ER retrograde traffic. The drugs Zinc cation and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and thyroid, and related phenotypes are Increased gamma-H2AX phosphorylation and growth/size/body region

19) Alopecia Areata
Alopecia Areata, also known as alopecia circumscripta, is related to alopecia universalis congenita and alopecia, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia Areata is AA1 (Alopecia Areata 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

20) Pityriasis Rubra Pilaris
Pityriasis Rubra Pilaris, also known as devergie's disease, is related to familial pityriasis rubra pilaris and psoriasis 13. An important gene associated with Pityriasis Rubra Pilaris is CARD14 (Caspase Recruitment Domain Family Member 14), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Alefacept and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and liver, and related phenotypes are palmoplantar keratoderma and papule

21) Influenza
Influenza, also known as flu, is related to avian influenza and swine influenza, and has symptoms including chills, fever and sore throat. An important gene associated with Influenza is IVNS1ABP (Influenza Virus NS1A Binding Protein), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Hops and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and brain, and related phenotypes are no effect and no effect

22) Ulcerative Colitis
Inflammatory Bowel Disease 1, also known as inflammatory bowel disease 1, is related to inflammatory bowel disease 19 and inflammatory bowel disease 17, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Inflammatory Bowel Disease 1 is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Magnesium citrate and Prucalopride have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and bone, and related phenotypes are growth delay and abdominal pain

23) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

24) Atopic Dermatitis
Dermatitis, Atopic, also known as atopic dermatitis, is related to allergic disease and dermatitis, atopic, 3, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis, Atopic is FLG (Filaggrin), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Cytokine Signaling in Immune system. The drugs Zinc oxide and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are cataract and ichthyosis

25) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

26) Dermatitis
Dermatitis, also known as eczema, is related to irritant dermatitis and dermatitis herpetiformis, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Salicylic acid and Titanium dioxide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are immune system and hematopoietic system

27) Graft-versus-host Disease
Graft-Versus-Host Disease, also known as graft-versus-host disease, susceptibility to, is related to bronchiolitis obliterans and acute graft versus host disease. An important gene associated with Graft-Versus-Host Disease is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Tacrolimus and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and t cells, and related phenotypes are elevated hepatic transaminase and skin erosion

28) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

29) Acne
Acne, also known as acne vulgaris, is related to sapho syndrome and hidradenitis suppurativa, and has symptoms including exanthema and pruritus. An important gene associated with Acne is NCSTN (Nicastrin), and among its related pathways/superpathways are Innate Immune System and Prolactin Signaling. The drugs Calcipotriol and Adapalene have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and thyroid, and related phenotypes are no effect and no effect

30) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

31) Systemic Lupus Erythematosus
Systemic Lupus Erythematosus, also known as lupus nephritis, is related to lupus erythematosus and autoimmune disease, and has symptoms including exanthema, pruritus and lupus-like rash. An important gene associated with Systemic Lupus Erythematosus is TREX1 (Three Prime Repair Exonuclease 1), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, bone marrow and skin, and related phenotypes are lupus nephritis and arthritis

32) Lupus Erythematosus
Lupus Erythematosus, also known as lupus, is related to systemic lupus erythematosus and systemic lupus erythematosus 16, and has symptoms including rashes, exanthema and pruritus. An important gene associated with Lupus Erythematosus is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and t cells, and related phenotypes are no effect and no effect

33) Fibrosis
Fibrosis of Extraocular Muscles, Congenital, 1, also known as fibrosis of extraocular muscles, congenital, 3b, is related to moebius syndrome and fibrosis of extraocular muscles, congenital, 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Fibrosis of Extraocular Muscles, Congenital, 1 is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Vesicle-mediated transport. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone marrow, and related phenotypes are esotropia and exotropia

34) Tuberculosis
Mycobacterium Tuberculosis 1, also known as tuberculosis, is related to pulmonary tuberculosis and miliary tuberculosis, and has symptoms including coughing, fever and pruritus. An important gene associated with Mycobacterium Tuberculosis 1 is MTBS1 (Mycobacterium Tuberculosis, Susceptibility To Infection By, 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Calcium carbonate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include lungs, lymph nodes and pericardium, and related phenotypes are fatigue and fever

35) Ischemia
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

36) Tendinopathy
Tendinitis, also known as tendinopathy, is related to patellar tendinitis and calcific tendinitis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Tendinitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Disease and MIF Mediated Glucocorticoid Regulation. The drugs Diclofenac and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and hypothalamus, and related phenotypes are homeostasis/metabolism and muscle

37) Autoimmune Disease
Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and systemic lupus erythematosus. An important gene associated with Autoimmune Disease is AIS4 (Autoimmune Disease, Susceptibility To, 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and skin, and related phenotypes are autoimmune antibody positivity and endocrine/exocrine gland

38) Uveitis
Uveitis is related to anterior uveitis and pars planitis. An important gene associated with Uveitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lidocaine and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

39) Allergic Contact Dermatitis
Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to 1,4-phenylenediamine allergic contact dermatitis and palladium allergic contact dermatitis. An important gene associated with Allergic Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Povidone K30 and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lymph node, and related phenotypes are immune system and respiratory system

40) Psoriasis
Psoriasis is related to psoriasis 7 and psoriasis 10, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis is MIR203A (MicroRNA 203a), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Metformin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

41) Polymyalgia Rheumatica
Temporal Arteritis, also known as polymyalgia rheumatica, is related to myocarditis and arteritic anterior ischemic optic neuropathy, and has symptoms including back pain, exanthema and muscle cramp. An important gene associated with Temporal Arteritis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and eye, and related phenotypes are joint stiffness and fatigue

42) Osteoporosis
Bone Mineral Density Quantitative Trait Locus 8, also known as osteoporosis, is related to osteoporosis and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Bone Mineral Density Quantitative Trait Locus 8 is BMND8 (Bone Mineral Density Quantiative Trait Locus 8). The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord.

43) Hyperlipidemia
Familial Hyperlipidemia, also known as familial hyperlipoproteinemia, is related to hyperlipoproteinemia, type v and hyperlipoproteinemia, type i. An important gene associated with Familial Hyperlipidemia is APOB (Apolipoprotein B), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Evolocumab and Dapagliflozin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and endothelial, and related phenotypes are no effect and no effect

44) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

45) Hyperglycemia
Hyperglycemia is related to type 1 diabetes mellitus and maturity-onset diabetes of the young, type 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Hyperglycemia is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are Metabolism and Nervous system development. The drugs Saxagliptin and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and brain, and related phenotypes are Decreased viability and Decreased viability

46) Ichthyosis
Ichthyosis, also known as ichthyoses, is related to ichthyosis, congenital, autosomal recessive 4b and autosomal recessive congenital ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Ichthyosis is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Keratinization and Prostaglandin 2 biosynthesis and metabolism FM. The drugs Ustekinumab and Emollients have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and lymph node, and related phenotypes are homeostasis/metabolism and growth/size/body region

47) Melanoma
Melanoma, also known as malignant melanoma, is related to skin melanoma and melanoma, cutaneous malignant 1, and has symptoms including exanthema and pruritus. An important gene associated with Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Vindesine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are normal and pigmentation

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