MARCHF8: A Potential Drug Target and Biomarker for Fungal Infections

Target Name: MARCHF8

NCBI ID: G220972

MARCHF8

MARCHF8: A Potential Drug Target and Biomarker for Fungal Infections

Fungal infections are a common pathology that affect millions of people worldwide and can cause significant morbidity and mortality. Fungi are complex organisms that can form both comminutants and pathogens, and their identification and treatment remains a significant challenge. One of the major challenges in fungal disease is the lack of effective targets for treatment, which has led to a limited treatment options for patients. However, the identification of potential drug targets and biomarkers can greatly improve our understanding of fungal infections and aid in the development of new treatments. In this article, we will discuss MARCHF8, a potential drug target and biomarker for fungal infections.

MARCHF8: The RING Finger Protein 178

MARCHF8, also known as RING- finger protein 178 (RFP178), is a protein that is expressed in a variety of organisms, including humans. It is a member of the MARCHF gene family, which is characterized by the presence of a characteristic motif known as a ring-shaped nucleotide-binding oligomerization domain (RING-NOD). MARCHF8 is a 21-kDa protein that was identified as a potential drug target and biomarker for fungal infections due to its unique structure and expression pattern.

Function and Localization

MARCHF8 is a nuclear protein that is primarily localized to the nuclei of cells. It plays a role in various cellular processes, including DNA replication, transcription, and gene regulation. MARCHF8 is also involved in the regulation of cell cycle progression and has been shown to play a role in the development of cancer. Additionally, MARCHF8 has been shown to be involved in the regulation of cellular immune responses, which is important for the fight against fungal infections.

Drug Interaction with MARCHF8

Given its potential involvement in both cancer and immune regulation, researchers have been interested in developing drugs that can target MARCHF8. One of the most promising strategies is the use of small molecules that can modulate the activity of MARCHF8. Researchers have identified a number of small molecules that have been shown to interact with MARCHF8 and have the potential to be used as drug candidates. These small molecules include inhibitors of DNA replication, transcription, and protein synthesis, as well as modulators of cellular signaling pathways that are involved in the regulation of cell cycle progression and the immune response.

MARCHF8 as a Biomarker

MARCHF8 has also been identified as a potential biomarker for fungal infections. The identification of MARCHF8 as a biomarker for fungal infections is based on the fact that MARCHF8 is expressed in a variety of fungal organisms and that it is involved in the regulation of cellular processes that are important for fungal growth and development. Additionally, the fact that MARCHF8 is a protein that is expressed in the nuclei of cells implies that it may be involved in the regulation of cellular processes that are important for the development and replication of fungal infections.

MARCHF8 has been shown to be involved in the regulation of fungal DNA replication and transcription, which are important for the development of fungal infections. Additionally, MARCHF8 has been shown to play a role in the regulation of the cell cycle, which is important for the growth and development of fungal cells. These findings suggest that MARCHF8 may be a useful biomarker for the diagnosis and treatment of fungal infections.

Conclusion

MARCHF8 is a protein that is expressed in a variety of organisms and has been shown to play a role in various cellular processes, including DNA replication, transcription, and gene regulation. Its unique structure and expression pattern make it a potential drug target and biomarker for fungal infections. The identification of small molecules that can interact with MARCHF8 is promising, and further research is needed to determine

Protein Name: Membrane Associated Ring-CH-type Finger 8

Functions: E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:34285233, PubMed:35019698, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:19117940, PubMed:19566897). Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins (PubMed:32934085). Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation (PubMed:35019698). Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses (PubMed:35019698, PubMed:34285233). Strongly blocks human immunodeficiency virus type 1 envelope glycoprotein incorporation into virions by down-regulating its cell surface expression. Blocks also ebola virus glycoprotein/GP incorporation via surface down-regulation (PubMed:32934085). Mediates 'Lys-63'-linked polyubiquitination of influenza M2 to target it to lysosome for degradation (PubMed:34285233). Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway (PubMed:28320822). Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination (PubMed:34183449). Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863)

The "MARCHF8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MARCHF8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets