MATCAP2: A Potential Drug Target and Biomarker for Pyruvate Deficiency

Target Name: MATCAP2

NCBI ID: G23366

MATCAP2

MATCAP2: A Potential Drug Target and Biomarker for Pyruvate Deficiency

Pyruvate is a crucial carbon source in the human body, and it is converted to acetyl-CoA by the enzyme pyruvate carboxylase (PCD) to produce carbon dioxide and lactate. CDP-PYRUVATE is the final step in the pyruvate metabolism. MATCAP2 (MutL homolog 2) is a gene that encodes the protein putative tyrosine carboxypeptidase (PTC), which is involved in the metabolism of pyruvate. MATCAP2 is a key enzyme in the pyruvate cycle, and its function is crucial for the proper functioning of the cell. MATCAP2 has also been suggested as a potential drug target and biomarker for pyruvate deficiency. In this article, we will discuss the structure and function of MATCAP2, and its potential as a drug target and biomarker.

Structure and Function of MATCAP2

MATCAP2 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and muscle. It is localized to the endoplasmic reticulum and can be nuclear exported to the cytoplasm. MATCAP2 has a molecular weight of 41 kDa and a calculated pI of 11.9. It has one known function, which is to catalyze the conversion of pyruvate to carbon dioxide and lactate.

The catalytic center of MATCAP2 is the active site, which is composed of the amino acids Asp-21, Asp-22, Asp-23, Asp-24, Asp-25, Asp-26, and Asp-27. The Asp-21 atom is involved in the catalytic mechanism, while the other amino acids Asp-22, Asp-23, Asp-24, Asp-25, Asp-26, and Asp-27 provide the structural stability of the protein.

MATCAP2 has a unique catalytic mechanism that is different from that of other enzymes in the pyruvate cycle. It is a non-canonical, ATP-dependent pyruvate carboxylase, which means that it uses ATP instead of the standard ATP. The ATP hydrolysis provides the energy required for the reaction. MATCAP2 has a highly conserved active site, which is similar to that of other enzymes in the pyruvate cycle.

MATCAP2 has been shown to have various functions, including the regulation of cellular processes such as cell growth, differentiation, and metabolism. MATCAP2 has been shown to play a role in the regulation of cellular metabolism, particularly the metabolism of pyruvate. It has been shown to increase the levels of pyruvate in the cytoplasm, which is necessary for the production of carbon dioxide and lactate.

MATCAP2 has also been shown to have a role in the regulation of cellular signaling pathways. It has been shown to be involved in the regulation of several signaling pathways, including the TOR signaling pathway, the PI3K/AKT signaling pathway, and the Hedgehog signaling pathway. MATCAP2 has also been shown to play a role in the regulation of cellular apoptosis, which is a critical mechanism that helps cells to remove damaged or unnecessary proteins.

Potential Drug Target and Biomarker for Pyruvate Deficiency

MATCAP2 has been shown to have a role in the regulation of cellular processes, including the metabolism of pyruvate. Therefore, it is a potential drug target for the treatment of pyruvate deficiency. Pyruvate is a crucial carbon source in the human body, and it is

Protein Name: Microtubule Associated Tyrosine Carboxypeptidase 2

Functions: Putative tyrosine carboxypeptidase

The "MATCAP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MATCAP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets