Target Name: MBOAT7
NCBI ID: G79143
Review Report on MBOAT7 Target / Biomarker Content of Review Report on MBOAT7 Target / Biomarker
MBOAT7
Other Name(s): Leukocyte receptor cluster member 4 | MBOA7_HUMAN | bladder and breast carcinoma-overexpressed gene 1 protein | LENG4 protein | LRC4 | O-acyltransferase domain-containing protein 7 | Leukocyte receptor cluster (LRC) member 4 | membrane bound O-acyltransferase domain containing 7 | LENG4 | hMBOA-7 | Lysophospholipid acyltransferase 7 | Lysophospholipid acyltransferase 7 (isoform 1) | LPIAT1 | leukocyte receptor cluster (LRC) member 4 | Lyso-PI acyltransferase | Membrane bound O-acyltransferase domain containing 7, transcript variant 2 | MBOAT7 variant 1 | lysophosphatidylinositol acyltransferase 1 | 1-acylglycerophosphatidylinositol O-acyltransferase | MBOA7 | Lysophospholipid acyltransferase 7 (isoform 2) | Membrane bound O-acyltransferase domain containing 7, transcript variant 1 | LPLAT 7 | MBOAT7 variant 2 | Malignant cell expression-enhanced gene/tumor progression-enhanced | malignant cell expression-enhanced gene/tumor progression-enhanced | lyso-PI acyltransferase | lysophosphatidylinositol acyltransferase | Lysophosphatidylinositol acyltransferase | lysophospholipid acyltransferase 11 | OACT7 | Membrane-bound O-acyltransferase domain-containing protein 7 | LPIAT | Bladder and breast carcinoma-overexpressed gene 1 protein | h-mboa-7 | LPLAT11 | LPLAT | BB1 | MRT57

MBOAT7: A Potential Drug Target and Biomarker

Introduction

MBOAT7, also known as leukocyte receptor cluster member 4, is a protein that is expressed in various tissues, including the brain, spleen, and lymphoid organs. It is a member of the MBOAT family, which includes several similar proteins that are involved in the regulation of immune cell function and cytokine signaling. MBOAT7 has been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

MBOAT7 Structure and Function

MBOAT7 is a type-I transmembrane protein that consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain consists of a N-terminus that is involved in protein-protein interactions and is known as the N-terminal domain . The transmembrane region consists of a single transmembrane protein and is known as the T-terminal domain. The intracellular domain consists of a single cytoplasmic tail that is involved in protein-protein interactions and is known as the C-terminal domain.

MBOAT7 is involved in the regulation of immune cell function and cytokine signaling. It is a member of the MBOAT family, which includes several similar proteins that are involved in the regulation of immune cell function and cytokine signaling. MBOAT7 has been shown to play a role in the regulation of T cell development and function, as well as the regulation of neurodegenerative disorders.

MBOAT7 as a Potential Drug Target

MBOAT7 has been identified as a potential drug target for several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. One of the main reasons for identifying MBOAT7 as a potential drug target is its involvement in the regulation of immune cell function and cytokine signaling. MBOAT7 has been shown to play a role in the regulation of T cell development and function, as well as the regulation of neurodegenerative disorders.

MBOAT7 has also been shown to be involved in the regulation of cancer cell growth and metastasis. Several studies have shown that MBOAT7 is expressed in various types of cancer cells, including breast, ovarian, and prostate cancer cells. Furthermore, MBOAT7 has been shown to play a role in the regulation of cancer cell survival and the development of cancer-associated superantigen (SAS).

MBOAT7 has also been shown to be involved in the regulation of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Several studies have shown that MBOAT7 is expressed in the brains of individuals with Alzheimer's disease and Parkinson's disease, and that it is involved in the regulation of neurodegenerate markers, including neurofilament tangles and neuroglial cells.

MBOAT7 has also been shown to be involved in the regulation of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Several studies have shown that MBOAT7 is expressed in the tissues of individuals with rheumatoid arthritis and multiple sclerosis, and that it is involved in the regulation of autoimmune markers, including T cells and inflammation.

MBOAT7 as a Biomarker

MBOAT7 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. One of the main reasons for identifying MBOAT7 as a potential biomarker is its expression in various tissues and its involvement in the regulation of immune cells function and cytokine signaling. MBOAT7 has been shown to be involved in the regulation of T cell development and function, as well as the regulation of neurodegenerative disorders and autoimmune diseases.

MBOAT7 has also been shown to be involved in

Protein Name: Membrane Bound O-acyltransferase Domain Containing 7

Functions: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128, PubMed:18094042). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18772128, PubMed:18094042). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259)

The "MBOAT7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MBOAT7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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