Marcks as A Potential Drug Target Or Biomarker (G4082)

Target Name: MARCKS

NCBI ID: G4082

MARCKS

Marcks as A Potential Drug Target Or Biomarker

MARCKS, also known as phosphomyristin, is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell signaling, particularly in the regulation of muscle growth and differentiation. MARCKS has also been shown to play a role in the development and progression of various diseases, including cancer. As a result, MARCKS has become a focus of interest for researchers as a potential drug target or biomarker.

The MARCKS protein is composed of four distinct chains: alpha, beta, gamma, and delta. These chains are held together by a disulfide bond, and the chains are held in a unique arrangement that allows for the formation of a monomeric form of the protein. This monomeric form is highly stable and has been shown to have a number of unique properties that make it an attractive target for drug development.

One of the key properties of MARCKS is its ability to interact with various signaling molecules. This interaction allows MARCKS to regulate the activity of a wide range of signaling pathways, including the TGF-beta pathway. TGF-beta is a well-known signaling pathway that is involved in the regulation of cell growth, differentiation, and survival. MARCKS has been shown to play a key role in the regulation of TGF-beta signaling by inhibiting the activity of the protein Smad4.

In addition to its role in TGF-beta signaling, MARCKS has also been shown to play a role in the regulation of cell adhesion. Adhesion is the process by which cells stick together and form tissues. MARCKS has been shown to be involved in the regulation of cell adhesion by interacting with the protein cadherin.

Another key property of MARCKS is its ability to interact with various signaling molecules on the cell surface. This interaction allows MARCKS to regulate the activity of a wide range of signaling pathways, including the regulation of cell survival and the regulation of the immune response.

In addition to its role in signaling pathways, MARCKS has also been shown to play a role in the regulation of muscle growth and differentiation. MARCKS has been shown to play a key role in the regulation of muscle cell proliferation and muscle fiber growth. In addition, MARCKS has also been shown to play a role in the regulation of muscle protein synthesis and the regulation of muscle contractions.

As a result of its unique properties and its involvement in a wide range of signaling pathways, MARCKS has become a focus of interest for researchers as a potential drug target or biomarker. Studies have shown that MARCKS can be effectively targeted with small molecules, such as inhibitors of the protein kinase Akt. In addition, researchers have also shown that MARCKS can be used as a biomarker for a wide range of diseases, including cancer.

One of the challenges in the development of MARCKS as a drug target or biomarker is the lack of understanding of its underlying biology. While much research has been done to understand the role of MARCKS in various signaling pathways, much of the biology of MARCKS remains unexplored. As a result, the development of MARCKS as a drug target or biomarker is still in its early stages, and much more research is needed to fully understand its potential and limitations.

In conclusion, MARCKS is a protein that has been shown to play a key role in the regulation of various signaling pathways, including TGF-beta, cell adhesion, and muscle growth and differentiation. Its unique properties and its involvement in a wide range of signaling pathways make it an attractive target for drug development. While much research has been done to understand the role of MARCKS, much more research is needed to fully understand its potential and limitations as a drug target or biomarker.

Protein Name: Myristoylated Alanine Rich Protein Kinase C Substrate

Functions: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

The "MARCKS Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MARCKS comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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