MARS2: The Multi-functional Methionyl-tRNA Synthetase 2 (G92935)

Target Name: MARS2

NCBI ID: G92935

MARS2

MARS2: The Multi-functional Methionyl-tRNA Synthetase 2

Methionyl-tRNA synthetase 2 (Mars2) is a protein that plays a crucial role in the regulation of protein synthesis in eukaryotic cells. It is a member of the tRNA synthetase family 6, which includes four subclasses: Mars2, Mars3, Mars4, and Mars5. Mars2 is widely expressed in various tissues and is responsible for synthesizing methylated tRNA for protein translation.

Mars2 is not only involved in protein synthesis but also in the regulation of translation efficiency, as well as the quality control of translated proteins. It is well established that Mars2 plays a role in the regulation of translation efficiency by modulating the activity of the translation factors, such as eIF4F and HIF1伪. These factors are involved in the recruitment of specific translation factors to the mRNA and in the initiation of translation. Mars2 has been shown to regulate the activity of these factors, thereby affecting the translation efficiency of the mRNA.

In addition to its role in translation regulation, Mars2 is also involved in the regulation of protein stability and turnover. It has been shown to play a role in the degradation of misfolded proteins, which is a process that is important for maintaining protein homeostasis and for maintaining cellular signaling.

Mars2 is also involved in the regulation of cellular signaling pathways, including cell growth, apoptosis, and inflammation. It has been shown to play a role in the regulation of cell cycle progression, and it is involved in the regulation of the DNA damage response.

Mars2 is a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, Mars2 has been shown to be involved in the regulation of cancer cell growth and has been used as a potential biomarker for cancer diagnosis and treatment. In addition, Mars2 has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease, and has been used as a potential biomarker for neurodegenerative diseases.

In conclusion, Mars2 is a multifunctional protein that plays a crucial role in the regulation of protein synthesis, translation efficiency, stability, and turnover in eukaryotic cells. It is a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of Mars2 in cellular signaling pathways and to develop effective treatments for these diseases.

Protein Name: Methionyl-tRNA Synthetase 2, Mitochondrial

The "MARS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MARS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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