WDPCP: A Protein Interaction Target for Drug Development (G51057)
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WDPCP: A Protein Interaction Target for Drug Development
WDPCP (hFRTZ) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. It is a member of the framework region family of proteins, which are involved in the formation of tight junctions, which are a type of cell-cell barrier that helps to maintain tissue structure and function.
One of the unique features of WDPCP is its ability to interact with several different proteins, including the transcription factor NF-kappa-B. This interaction between WDPCP and NF-kappa-B has been shown to play a role in a variety of physiological processes, including the regulation of inflammation, stress response, and cell survival.
In addition to its interaction with NF-kappa-B, WDPCP has also been shown to interact with several other proteins, including the protein PDGF-BB. This interaction between WDPCP and PDGF-BB has been shown to play a role in the regulation of cell proliferation and survival, and may be a potential drug target for the treatment of various diseases.
WDPCP has also been shown to interact with the protein T-cell factor (TGF-1). This interaction between WDPCP and TGF-1 has been shown to play a role in the regulation of cellular processes such as cell growth, differentiation, and survival.
In addition to its interactions with these proteins, WDPCP has also been shown to play a role in the regulation of cellular processes that are important for the development and maintenance of tissues. For example, studies have shown that WDPCP plays a role in the regulation of angiogenesis, the formation of new blood vessels, and the regulation of blood pressure.
Overall, the protein WDPCP is a promising drug target for the treatment of various diseases. Its interactions with important proteins such as NF-kappa-B, PDGF-BB, and TGF-1, as well as its role in the regulation of cellular processes important for tissue development and maintenance, make it an attractive target for research and development of new therapies.
Protein Name: WD Repeat Containing Planar Cell Polarity Effector
Functions: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity)
The "WDPCP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDPCP comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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