Target Name: WDR12
NCBI ID: G55759
Review Report on WDR12 Target / Biomarker Content of Review Report on WDR12 Target / Biomarker
WDR12
Other Name(s): Ribosome biogenesis protein WDR12 (isoform 1) | FLJ10881 | WD repeat domain 12 | WD repeat domain 12, transcript variant 1 | WD repeat-containing protein 12 | YTM1 | FLJ12719 | WDR12 variant 1 | WDR12_HUMAN | Ribosome biogenesis protein WDR12 | FLJ12720

WDR12: A promising drug target for Ribosome Biogenesis Protein

Ribosome biogenesis protein WDR12 is an essential protein that plays a crucial role in the regulation of protein synthesis in eukaryotic cells. WDR12 is expressed in most eukaryotic cells and is highly conserved across different species. It is composed of two isoforms, WDR12-1 and WDR12-2, which differ in their N-terminal and C-terminal extensions. In this article, we will focus on WDR12-1, the more abundant isoform, and its potential as a drug target.

WDR12-1: Structure and Function

WDR12-1 is a 21 kDa protein that contains 115 amino acid residues. It has a characteristic Rossmann-fold structure that is commonly found in proteins involved in protein-protein interactions. WDR12-1 has been shown to interact with several protein partners, including GFP-伪2, a GFP-tagged protein that plays a role in the regulation of protein synthesis inositol-requiring signaling (IRIS) pathway.

WDR12-1 has been shown to regulate protein synthesis by interacting with the eIF4E complex, which is responsible for loading foreign proteins onto the ribosome. The N-terminal extension of WDR12-1 contains a putative N-terminal domain that is involved in protein-protein interactions and may function as a structural component of the eIF4E complex. The C-terminal extension of WDR12-1 contains a T-loop and a Leucinerich repeat, both of which are known to play important roles in protein stability and interactions.

WDR12-1 has been shown to be involved in several cellular processes, including cell growth, differentiation, and stress response. For example, WDR12-1 has been shown to be involved in the regulation of cell cycle progression, cell migration, and the response to oxidative stress. In addition, WDR12-1 has been shown to play a role in the regulation of protein synthesis and may be a potential drug target for diseases that are characterized by disruptions in protein synthesis, such as cancer, neurodegenerative diseases, and diseases that affect the balance of membrane potential.

Drug Target Potential

WDR12-1 is a potential drug target due to its involvement in several cellular processes that are affected by disruptions in protein synthesis. Cancer is a disease that is characterized by disruptions in the regulation of protein synthesis, and targeting WDR12-1 may be a promising approach to cancer treatment. For example, studies have shown that inhibition of WDR12-1 can lead to the inhibition of cell growth and the inhibition of the formation of new blood vessels, which are both hallmarks of cancer.

In addition, disruptions in protein synthesis have also been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. WDR12-1 has been shown to play a role in the regulation of protein synthesis and may be a potential drug target for these diseases.

WDR12-1 has also been shown to play a role in the regulation of the cytoskeleton and the intercellular matrix, which are involved in the regulation of cell behavior and the development of tissues. In addition, disruptions in the regulation of protein synthesis have also been implicated in diseases that affect the balance of membrane potential, such as epilepsy and migraine. Targeting WDR12-1 may be a promising approach to treating these diseases.

Conclusion

WDR12-1 is a protein that has been shown to play a role in the regulation of protein synthesis in eukaryotic cells. It is expressed in most eukaryotic cells and has been shown to interact with several protein partners, including GFP-伪2. The N-terminal and C-terminal extensions of WDR12-1 have been shown to play important roles in

Protein Name: WD Repeat Domain 12

Functions: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome

The "WDR12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDR12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B