GPR161: A Protein That Regulates Cellular Signaling and May Be A Drug Target for Many Diseases
GPR161: A Protein That Regulates Cellular Signaling and May Be A Drug Target for Many Diseases
GPR161, also known as G-protein coupled receptor 161 isoform 1, is a protein that plays a crucial role in cellular signaling. It is a member of the G-protein coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling. GPR161 is expressed in many tissues and cells, including the brain, pancreas, and gastrointestinal tract.
GPR161 is a 14-kDa protein that consists of an extracellular region, a transmembrane region, and an intracellular region. The extracellular region consists of a N-terminal伪-helix, a 尾-sheet, and a C-terminal tail. The transmembrane region The intracellular region consists of a single intracellular伪-helix.
GPR161 is involved in many cellular signaling pathways. For example, it is involved in the regulation of pain, inflammation, and neurotransmitter signaling. GPR161 is also involved in the regulation of cell survival and proliferation.
GPR161 is a potential drug target because of its involvement in cellular signaling. Many diseases, including pain, inflammation, and neurodegenerative disorders, are caused by the dysregulation of cellular signaling pathways. GPR161 may be a useful target for these diseases because of its involvement in these signaling pathways.
GPR161 is also a potential biomarker for many diseases. For example, GPR161 may also be used as a biomarker for the diagnosis and progression of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. of pain, inflammation, and cancer.
GPR161 is also involved in many cellular signaling pathways that are important for human health. For example, GPR161 is involved in the regulation of pain signaling, which is important for the maintenance of brain health and the treatment of pain. GPR161 is also involved in the regulation of inflammation, which is important for the immune response and the regulation of tissue repair.
GPR161 may also be involved in the regulation of neurotransmitter signaling, which is important for the transmission of signals in the brain. GPR161 is involved in the regulation of the neurotransmitter GABA, which is an important neurotransmitter that plays a key role in the regulation of pain and anxiety.
GPR161 is a protein that plays a crucial role in cellular signaling. It is a member of the GPCR family and is involved in many cellular signaling pathways that are important for human health. GPR161 may be a potential drug target and biomarker for the diagnosis and treatment of many diseases.
Protein Name: G Protein-coupled Receptor 161
Functions: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity)
The "GPR161 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR161 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1 | GPX1P1 | GPX2 | GPX3 | GPX4 | GPX5 | GPX6 | GPX7 | GPX8 | GRAMD1A | GRAMD1B | GRAMD1C | GRAMD2A | GRAMD2B | GRAMD4 | GRAMD4P2 | GRAMD4P5 | GRAMD4P7 | Granzyme | GRAP | GRAP2 | GRAPL | GRAPL-AS1 | GRASLND | GRB10
