MAP4K3: A Protein Regulator of Cell Signaling Pathways (G8491)

Target Name: MAP4K3

NCBI ID: G8491

MAP4K3

MAP4K3: A Protein Regulator of Cell Signaling Pathways

MAP4K3, also known as Mitogen-activated protein kinase kinase kinase 3 (ISOFORM 1), is a protein that plays a crucial role in cell signaling pathways. It is a key regulator of theMAPK/ERK signaling pathway, which is involved in various cellular processes such as cell growth, differentiation, and response to stimuli.

MAP4K3 is a 21kDa protein that is expressed in various tissues, including muscle, brain, and heart. It is a serine/thruster protein, which means that it consists of a catalytic active center and a non-catalytic carboxy terminal region. The catalytic active center is the site of the protein's catalytic activity, where it interacts with other proteins to regulate cellular signaling pathways.

MAP4K3 functions as a kinase, which means it can catalyze the transfer of a phosphate group from other proteins to itself. This process is known as phosphorylation, and it allows the protein to regulate the activity of downstream target proteins. In response to MAP4K3 phosphorylation, target proteins can undergo various changes, including changes in their activity, localization, and stability.

One of the most well-known functions of MAP4K3 is its role in the MAPK/ERK signaling pathway. This pathway is involved in the regulation of various cellular processes, including cell growth, differentiation, and response to stimuli. MAP4K3 is a key regulator of this pathway, and its absence has been linked to various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

MAP4K3 is also involved in the regulation of cell adhesion and migration. It has been shown to play a role in the regulation of tight junction formation in various tissues, including the brain. Additionally, MAP4K3 has been shown to be involved in the regulation of cell cycle progression, and it has been shown to play a role in the regulation of apoptosis, a process that is involved in the cell's natural death.

MAP4K3 is also involved in the regulation of inflammation and immune response. It has been shown to play a role in the regulation of various immune cells, including T cells and macrophages. Additionally, MAP4K3 has been shown to play a role in the regulation of inflammation, and it has been shown to play a role in the development of various inflammatory diseases.

MAP4K3 is also involved in the regulation of pain perception and neurotransmission. It has been shown to play a role in the regulation of pain sensitivity and the transmission of pain signals through various neural circuits. Additionally, MAP4K3 has been shown to play a role in the regulation of neurotransmitter release and neurotransmission, and its absence has been linked to various neurological disorders.

MAP4K3 is a potential drug target and has been shown to be involved in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.MAP4K3 has been shown to play a role in the regulation of various cellular signaling pathways, including the MAPK/ERK signaling pathway, cell adhesion and migration, cell cycle progression, inflammation and immune response, and pain perception and neurotransmission. Its presence or absence has been linked to various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In conclusion, MAP4K3 is a protein that plays a crucial role in cell signaling pathways. It is a key regulator of theMAPK/ERK signaling pathway, and its absence has been linked to various diseases.MAP4K3 is a potential drug target and its study may provide new insights into the regulation of various cellular signaling pathways and their role in the development of various diseases.

Protein Name: Mitogen-activated Protein Kinase Kinase Kinase Kinase 3

Functions: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway

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