Understanding MAP2K5: A Potential Drug Target for Cancer and Other Diseases

Target Name: MAP2K5

NCBI ID: G5607

MAP2K5

Understanding MAP2K5: A Potential Drug Target for Cancer and Other Diseases

MAP2K5, also known as Mitogen-activated protein kinase kinase 5, is a protein that plays a crucial role in cellular signaling. It is a member of the MAPK/ERK signaling pathway, which regulates various cellular processes, including cell growth, differentiation, and survival. Unfortunately, MAP2K5 has also been implicated in the development and progression of various diseases, including cancer. As a result, it has become an attractive drug target for researchers to explore.

MAP2K5 is a 21-kDa protein that is expressed in various tissues and cells. It is highly conserved, with a calculated pI of 5.5. This protein is involved in several cellular signaling pathways, including the G1/S transition, G0/G1 transition, and the G2/M transition. MAP2K5 plays a key role in regulating the growth and differentiation of various cell types, and it is also involved in the regulation of cell survival.

One of the well-documented functions of MAP2K5 is its role in cell proliferation. MAP2K5 has been shown to promote the growth of various cell types, including cancer cells. It has been shown that MAP2K5 can induce the growth of cancer cells in a variety of models, including the parental mouse xenograft model and the RKO mouse model. Additionally, it has been shown that MAP2K5 can also promote the growth of normal tissues, such as the human scalp hair follicle.

Another function of MAP2K5 is its role in cell survival. MAP2K5 has been shown to promote the survival of various cell types, including cancer cells. It has been shown that MAP2K5 can induce the expression of genes that promote cell survival, such as the expression of the survival factor PDGF-BB. Additionally, it has been shown that MAP2K5 can also play a role in the regulation of cell death, by promoting the expression of genes that promote cell apoptosis.

MAP2K5 has also been implicated in the development and progression of various diseases, including cancer. For example, it has been shown that MAP2K5 is involved in the regulation of the growth and survival of various cancer types, including breast cancer and colon cancer. Additionally, it has been shown that MAP2K5 is involved in the regulation of the angiogenesis of various cancer types, by promoting the growth of blood vessels that supply the tumors.

Despite its involvement in several cellular signaling pathways, MAP2K5 is not well understood. There are currently few research studies focused on MAP2K5, and many of the studies that do exist are limited in their scope and quality. As a result, there is a need for further research to be conducted on MAP2K5, in order to fully understand its functions and potential as a drug target.

In conclusion, MAP2K5 is a protein that plays a crucial role in cellular signaling. It is involved in several cellular signaling pathways, including the G1/S transition, G0/G1 transition, and the G2/M transition. MAP2K5 has also been implicated in the development and progression of various diseases, including cancer. As a result, MAP2K5 is an attractive drug target for researchers to explore, with potential for the development of new treatments for a variety of diseases.

Protein Name: Mitogen-activated Protein Kinase Kinase 5

Functions: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis

The "MAP2K5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAP2K5 comprehensively, including but not limited to:
•   general information;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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